Successful Treatment of Refractory Landau–Kleffner Syndrome With Memantine in a Child With Grin2a Gain-Of-Function Variant

Successful Treatment of Refractory Landau–Kleffner Syndrome With Memantine in a Child With Grin2a Gain-Of-Function Variant Publisher

Mohammadi M ; Badv R S ; Rezaei Z ; Zangooie A ; Asgari R ; Mashayekhi N

Source: Iranian Journal of Child Neurology Published:2026

Abstract

Landau-Kleffner syndrome and related epilepsy-aphasia spectrum disorders are characterized by childhood-onset language regression, sleep-activated epileptiform activity, and frequently refractory seizures. This case report describe a boy with normal early development who developed progressive aphasia and non-motor seizures around age three, with electroencephalographic findings consistent with spike-wave activation during slow sleep, while neuroimaging and metabolic evaluations were normal. Standard antiseizure medications and repeated immunotherapy provided no sustained benefit. Genetic testing at age 12 identified a pathogenic heterozygous GRIN2A gain-of-function missense variant (p.T531M), guiding initiation of targeted therapy with memantine, and an NMDA receptor antagonist. Following memantine treatment, the patient showed marked improvement in speech and social interaction together with reduced sleep-related epileptiform discharges, although some deficits persisted. This case underscores the value of early genetic evaluation in refractory epilepsy-aphasia syndromes and supports the potential role of precision NMDA-modulating therapy in GRIN2A-associated epileptic encephalopathy. © 2026, Iranian Child Neurology Society. All rights reserved.

Style	Citing Format
MLA	Mohammadi M, et al.. "Successful Treatment of Refractory Landau–Kleffner Syndrome With Memantine in a Child With Grin2a Gain-Of-Function Variant." Iranian Journal of Child Neurology, vol. 20, no. 3, 2026, pp. 87-93.
APA	Mohammadi M, Badv R S, Rezaei Z, Zangooie A, Asgari R, Mashayekhi N (2026). Successful Treatment of Refractory Landau–Kleffner Syndrome With Memantine in a Child With Grin2a Gain-Of-Function Variant. Iranian Journal of Child Neurology, 20(3), 87-93.
Chicago	Mohammadi M, Badv R S, Rezaei Z, Zangooie A, Asgari R, Mashayekhi N. "Successful Treatment of Refractory Landau–Kleffner Syndrome With Memantine in a Child With Grin2a Gain-Of-Function Variant." Iranian Journal of Child Neurology 20, no. 3 (2026): 87-93.
Harvard	Mohammadi M et al. (2026) 'Successful Treatment of Refractory Landau–Kleffner Syndrome With Memantine in a Child With Grin2a Gain-Of-Function Variant', Iranian Journal of Child Neurology, 20(3), pp. 87-93.
Vancouver	Mohammadi M, Badv R S, Rezaei Z, Zangooie A, Asgari R, Mashayekhi N. Successful Treatment of Refractory Landau–Kleffner Syndrome With Memantine in a Child With Grin2a Gain-Of-Function Variant. Iranian Journal of Child Neurology. 2026;20(3):87-93.
BibTex	@article{ author = {Mohammadi M and Badv R S and Rezaei Z and Zangooie A and Asgari R and Mashayekhi N}, title = {Successful Treatment of Refractory Landau–Kleffner Syndrome With Memantine in a Child With Grin2a Gain-Of-Function Variant}, journal = {Iranian Journal of Child Neurology}, volume = {20}, number = {3}, pages = {87-93}, year = {2026} }
RIS	TY - JOUR AU - Mohammadi M AU - Badv R S AU - Rezaei Z AU - Zangooie A AU - Asgari R AU - Mashayekhi N TI - Successful Treatment of Refractory Landau–Kleffner Syndrome With Memantine in a Child With Grin2a Gain-Of-Function Variant JO - Iranian Journal of Child Neurology VL - 20 IS - 3 SP - 87 EP - 93 PY - 2026 ER -

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