Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Immunoglobulin G Levels in Neonates After Receiving Phototherapy Publisher



Mirnia K1 ; Saeedi M1 ; Sangsari R1 ; Mokhtarian Zavareh F2 ; Mirnia V3 ; Rezaei N4, 5, 6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Division of Neonatology, Department of Pediatrics, Children’s Medical Center, Pediatric Center of Excellence, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Pediatrics, Children’s Medical Center, Pediatric Center of Excellence, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Faculty of Paramedicine, Babol University Medical Sciences, Babol, Iran
  4. 4. Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Network of Immunity in Infection, Malignancy and Autoimmunity, Universal Scientific Education and Research Network, Tehran, Iran
  6. 6. Department of Immunology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Pediatrics Published:2023


Abstract

Background: Most cases of newborn hyperbilirubinemia are physiologic; however, excessive unconjugated bilirubin is a potential neurotoxin. Phototherapy treats moderate to severe hyperbilirubinemia in addition to severe jaundice. If phototherapy increases immunoglobulin G (IgG) clearance, there is a chance of humoral immune disorders. Objectives: The purpose of the study was to investigate the effect of phototherapy on the level of IgG in neonates. Methods: This study investigated 40 full-term newborns with hyperbilirubinemia. Blood samples were taken before and 72 hours after phototherapy. The IgG level was measured by calorimetry tests. Results: Phototherapy resulted in a decrease in IgG levels. The IgG level significantly decreased from 833.135 to 720.185 mg/dL. Before phototherapy, 12.5% of the population had low IgG levels; however, 32.5% had low IgG levels after the treatment. Conclusions: According to the results of the study, intensive phototherapy caused a reduction in IgG levels. Since there was no significant decrease in IgG levels in neonates who received conventional phototherapy, it can be concluded that this treatment is safe in terms of IgG levels. © 2023, Author(s).
Related Docs
1. Comparison of Conventional Phototherapy and Phototherapy Along With Kangaroo Mother Care on Cutaneous Bilirubin of Neonates With Physiological Jaundice, Journal of Maternal-Fetal and Neonatal Medicine (2019)