Evaluation of Nanocarrier Targeted Drug Delivery of Capecitabine-Pamam Dendrimer Complex in a Mice Colorectal Cancer Model

Evaluation of Nanocarrier Targeted Drug Delivery of Capecitabine-Pamam Dendrimer Complex in a Mice Colorectal Cancer Model Pubmed

Nabavizadeh F¹ ; Fanaei H¹ ; Imani A¹ ; Vahedian J² ; Amoli FA¹ ; Ghorbi J³ ; Sohanaki H¹ ; Mohammadi SM¹ ; Golchoobian R¹

Show Affiliations

1. Departement of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Surgery, Firuzgar Hospital, Iran University of Medical Sciences, Tehran, Iran
3. Department of Bio-Medical Engineering and Medical Physics, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Acta Medica Iranica Published:2016

Abstract

Capecitabine, an effective anticancer drug in colorectal cancer chemotherapy, may create adverse side effects on healthy tissues. In the present study, we first induced colon adenocarcinoma with azoxymethane, a carcinogen agent, and then investigated the potentiality of polyamidoamine (PAMAM) dendrimer to improve capecitabine therapeutic index and decrease its adverse side effects on healthy tissues like liver and bone marrow. Other variables such as nanoparticle concentrations have also been investigated. Drug loading concentration (DLC) and encapsulation efficiency (EE) were calculated for capecitabine/dendrimer complex. Experimental results showed an increase in DLC percentage resulted from elevated capecitabine/dendrimer ratio. Capecitabine/dendrimer complex could reduce tumor size and adverse side effects in comparison with free capecitabine form. © 2016 Tehran University of Medical Sciences. All rights reserved.

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Style	Citing Format
MLA	Nabavizadeh F, et al.. "Evaluation of Nanocarrier Targeted Drug Delivery of Capecitabine-Pamam Dendrimer Complex in a Mice Colorectal Cancer Model." Acta Medica Iranica, vol. 54, no. 8, 2016, pp. 485-493.
APA	Nabavizadeh F, Fanaei H, Imani A, Vahedian J, Amoli FA, Ghorbi J, Sohanaki H, Mohammadi SM, Golchoobian R (2016). Evaluation of Nanocarrier Targeted Drug Delivery of Capecitabine-Pamam Dendrimer Complex in a Mice Colorectal Cancer Model. Acta Medica Iranica, 54(8), 485-493.
Chicago	Nabavizadeh F, Fanaei H, Imani A, Vahedian J, Amoli FA, Ghorbi J, Sohanaki H, Mohammadi SM, Golchoobian R. "Evaluation of Nanocarrier Targeted Drug Delivery of Capecitabine-Pamam Dendrimer Complex in a Mice Colorectal Cancer Model." Acta Medica Iranica 54, no. 8 (2016): 485-493.
Harvard	Nabavizadeh F et al. (2016) 'Evaluation of Nanocarrier Targeted Drug Delivery of Capecitabine-Pamam Dendrimer Complex in a Mice Colorectal Cancer Model', Acta Medica Iranica, 54(8), pp. 485-493.
Vancouver	Nabavizadeh F, Fanaei H, Imani A, Vahedian J, Amoli FA, Ghorbi J, et al.. Evaluation of Nanocarrier Targeted Drug Delivery of Capecitabine-Pamam Dendrimer Complex in a Mice Colorectal Cancer Model. Acta Medica Iranica. 2016;54(8):485-493.
BibTex	@article{ author = {Nabavizadeh F and Fanaei H and Imani A and Vahedian J and Amoli FA and Ghorbi J and Sohanaki H and Mohammadi SM and Golchoobian R}, title = {Evaluation of Nanocarrier Targeted Drug Delivery of Capecitabine-Pamam Dendrimer Complex in a Mice Colorectal Cancer Model}, journal = {Acta Medica Iranica}, volume = {54}, number = {8}, pages = {485-493}, year = {2016} }
RIS	TY - JOUR AU - Nabavizadeh F AU - Fanaei H AU - Imani A AU - Vahedian J AU - Amoli FA AU - Ghorbi J AU - Sohanaki H AU - Mohammadi SM AU - Golchoobian R TI - Evaluation of Nanocarrier Targeted Drug Delivery of Capecitabine-Pamam Dendrimer Complex in a Mice Colorectal Cancer Model JO - Acta Medica Iranica VL - 54 IS - 8 SP - 485 EP - 493 PY - 2016 ER -

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