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Resveratrol Supplementation and Flow-Mediated Dilation: A Systematic Review Publisher



Emamat H1 ; Djafarian K2 ; Tangestani H3 ; Hekmatdoost A4 ; Shabbidar S3
Authors

Source: Nutrition and Food Science Published:2019


Abstract

Purpose: This study aims to systematically review randomized clinical trials (RCTs) evaluated the effects of resveratrol on vascular flow-mediated dilation (FMD). Design/methodology/approach: All published RCTs in English were systematically searched on PubMed and Scopus search engines up to October 2017. A total of 61 studies were found through search databases. The outcome variable of interest was FMD. Six articles which met inclusion criteria were included in this study. Findings: From six studies, four showed a significant improvement in FMD after resveratrol supplementation acutely or chronically in subjects with cardio-metabolic risk factors. Two other studies did not show any significant effect of resveratrol on FMD. Originality/value: The authors systematically reviewed the effectiveness of resveratrol supplementation on FMD for the first time. The findings suggest that pure resveratrol supplementation may have beneficial effects on endothelium dependent vasodilatation indicator, FMD. © 2018, Emerald Publishing Limited.
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