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Covid-19 Associated Central Nervous System Manifestations, Mental and Neurological Symptoms: A Systematic Review and Meta-Analysis Publisher Pubmed



Soltani S1, 2 ; Tabibzadeh A3 ; Zakeri A4 ; Zakeri AM5 ; Latifi T1 ; Shabani M1 ; Pouremamali A6 ; Erfani Y7 ; Pakzad I8 ; Malekifar P9 ; Valizadeh R10 ; Zandi M1, 11 ; Pakzad R12, 13
Authors
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Authors Affiliations
  1. 1. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, 1417613151, Iran
  2. 2. Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, 1417613151, Iran
  3. 3. Department of Virology, Iran University of Medical Sciences, Tehran, 1449614535, Iran
  4. 4. Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, 111-14115, Iran
  5. 5. Pediatric Surgery Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, 22439962, Iran
  6. 6. Department of Medical Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, 111-14115, Iran
  7. 7. Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Tehran University Medical Sciences, Tehran, 1417613151, Iran
  8. 8. Department of Microbiology, School of Allied Medical Sciences, Ilam University Medical Sciences, Ilam, 6939177143, Iran
  9. 9. Department of Epidemiology, School of Public Health, Tehran University Medical Sciences, Tehran, 1417613151, Iran
  10. 10. Department of Psychiatry, Psychosocial Injures Research Center, Ilam University Medical Sciences, Ilam, 6939177143, Iran
  11. 11. Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, 1417613151, Iran
  12. 12. Department of Epidemiology, Faculty of Health, Ilam University Medical Sciences, Ilam, 6939177143, Iran
  13. 13. Noor Research Center for Ophthalmic Epidemiology, Noor Eye Hospital, Tehran, 1417613151, Iran

Source: Reviews in the Neurosciences Published:2021


Abstract

The ongoing pandemic of Coronavirus disease 2019 (COVID-19) has infected more than 27 million confirmed cases and 8,90,000 deaths all around the world. Verity of viral infections can infect the nervous system; these viral infections can present a wide range of manifestation. The aim of the current study was to systematically review the COVID-19 associated central nervous system manifestations, mental and neurological symptoms. For that we conducted a comprehensive systematic literature review of four online databases, including Web of Science, PubMed, Scopus and Embase. All relevant articles that reported psychiatric/psychological symptoms or disorders in COVID-19 without considering time and language restrictions were assessed. All the study procedures were performed based on the PRISMA criteria. Due to the screening, 14 studies were included. The current study result indicated that, the pooled prevalence of CNS or mental associated disorders with 95% CI was 50.68% (6.68-93.88). The most prevalence symptoms were hyposmia/anosmia/olfactory dysfunction (number of study: 10) with 36.20% (14.99-60.51). Only one study reported numbness/paresthesia and dysphonia. Pooled prevalence of numbness/paresthesia and dysphonia was 5.83% (2.17-12.25) and 2.39% (10.75-14.22). The pooled prevalence of depression and anxiety was 3.52% (2.62-4.54) and 13.92% (9.44-19.08). Our findings demonstrate that COVID-19 has a certain relation with neurological symptoms. The hypsomia, anosmia or olfactory dysfunction was most frequent symptom. Other symptoms were headache or dizziness, dysgeusia or ageusia, dysphonia and fatigue. Depression, anxiety, and confusion were less frequent symptoms. © 2020 Walter de Gruyter GmbH, Berlin/Boston 2020.
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