Association Between Herpes Simplex Virus Types 1 and 2 With Cardiac Myxoma

Association Between Herpes Simplex Virus Types 1 and 2 With Cardiac Myxoma Publisher Pubmed

Anvari MS¹ ; Sabagh M¹ ; Goodarzynejad H² ; Ziaei S¹ ; Boroumand MA¹ ; Pourgholi L¹ ; Jenab Y³ ; Abbasi K⁴

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1. Department of pathology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Clinical and Experimental Research, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
3. Department of cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
4. Department of cardiac surgery, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Cardiovascular Pathology Published:2017

Abstract

Most cases of atrial myxoma are sporadic, and the exact etiology is unknown. We examined if herpes simplex virus (HSV)-1 and HSV-2 antigens and/or DNA could be detected in a cohort of Iranian patients with cardiac myxomas. From July 2004 to June 2014, among a total of 36,703 patients undergoing open heart surgeries, consecutive patients with cardiac myxoma who were treated by surgical excision at our center included in this study. Of 73 patients studied, 56% were female with a mean age of 54 years (ranging from 23 to 77 years). Seventy-four myxomas were surgically removed from 73 patients, since one patient had two myxomas which were located on both the right atrium and right ventricle. The materials for this analysis were retrospectively gathered from extracted tumors that stored in a pathology bank of tissue paraffin blocks. The formalin fixed paraffin embedded tissue samples were investigated for HSV genomic DNA by both immunohistochemistry (IHC) and polymerase chain reaction (PCR) analysis. In all 74 cases there was no presence of HSV 1 and HSV 2 infection. This suggests that HSV may not play a role in sporadic cardiac myxomas; however, evidence for such association is currently lacking, and further studies are required to determine such a role. © 2017

Style	Citing Format
MLA	Anvari MS, et al.. "Association Between Herpes Simplex Virus Types 1 and 2 With Cardiac Myxoma." Cardiovascular Pathology, vol. 27, no. , 2017, pp. 31-34.
APA	Anvari MS, Sabagh M, Goodarzynejad H, Ziaei S, Boroumand MA, Pourgholi L, Jenab Y, Abbasi K (2017). Association Between Herpes Simplex Virus Types 1 and 2 With Cardiac Myxoma. Cardiovascular Pathology, 27(), 31-34.
Chicago	Anvari MS, Sabagh M, Goodarzynejad H, Ziaei S, Boroumand MA, Pourgholi L, Jenab Y, Abbasi K. "Association Between Herpes Simplex Virus Types 1 and 2 With Cardiac Myxoma." Cardiovascular Pathology 27, no. (2017): 31-34.
Harvard	Anvari MS et al. (2017) 'Association Between Herpes Simplex Virus Types 1 and 2 With Cardiac Myxoma', Cardiovascular Pathology, 27(), pp. 31-34.
Vancouver	Anvari MS, Sabagh M, Goodarzynejad H, Ziaei S, Boroumand MA, Pourgholi L, et al.. Association Between Herpes Simplex Virus Types 1 and 2 With Cardiac Myxoma. Cardiovascular Pathology. 2017;27():31-34.
BibTex	@article{ author = {Anvari MS and Sabagh M and Goodarzynejad H and Ziaei S and Boroumand MA and Pourgholi L and Jenab Y and Abbasi K}, title = {Association Between Herpes Simplex Virus Types 1 and 2 With Cardiac Myxoma}, journal = {Cardiovascular Pathology}, volume = {27}, number = {}, pages = {31-34}, year = {2017} }
RIS	TY - JOUR AU - Anvari MS AU - Sabagh M AU - Goodarzynejad H AU - Ziaei S AU - Boroumand MA AU - Pourgholi L AU - Jenab Y AU - Abbasi K TI - Association Between Herpes Simplex Virus Types 1 and 2 With Cardiac Myxoma JO - Cardiovascular Pathology VL - 27 IS - SP - 31 EP - 34 PY - 2017 ER -

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