Potential New Pharmacological Agents Derived From Medicinal Plants for the Treatment of Pancreatic Cancer Publisher Pubmed



Azimi H¹ ; Khakshur AA¹ ; Abdollahi M¹ ; Rahimi R² Show Affiliations
Source: Pancreas Published:2015

Abstract

In the present article, we reviewed plants and phytochemical compounds demonstrating beneficial effects in pancreatic cancer to find new sources of pharmaceutical agents. For this purpose, Scopus, PubMed, Web of Science, and Google scholar were searched for plants or herbal components with beneficial effects in the treatment of pancreatic cancer. Data were collected up to January 2013. The search terms were plant, herb, herbal therapy, or phytotherapy and pancreatic cancer or pancreas. All of the human in vivo and in vitro studies were included. According to studies, among diverse plants and phytochemicals, 12 compounds including apigenin, genistein, quercetin, resveratrol, epigallocatechin gallate, benzyl isothiocyanate, sulforaphane, curcumin, thymoquinone, dihydroartemisinin, cucurbitacin B, and perillyl alcohol have beneficial action against pancreatic cancer cells through 4 or more mechanisms. Applying their plausible synergistic effects can be an imperative approach for finding new efficient pharmacological agents in the treatment of pancreatic cancer. © 2014 Lippincott Williams & Wilkins.