Tehran University of Medical Sciences

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Proteins Brighten the Brain Publisher Pubmed



Zareshahabadi A1, 2 ; Ataei A1 ; Rezaei N3, 4, 5, 6
Authors
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Authors Affiliations
  1. 1. Psychiatry and Psychology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. NeuroImmunology Research Association (NIRA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  3. 3. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. NeuroImaging Network (NIN), Universal Scientific Education and Research Network (USERN), Los Angeles, CA, United States
  6. 6. Systematic Review and Meta-Analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Boston, MA, United States

Source: Life Sciences Published:2016


Abstract

Through selective activation/inhibition or dissection of neuronal circuits, optogenetic tools have raised hopes for a better understanding of neuropsychiatric mechanisms and therapeutic targets for various disorders. Although, overcoming serious limitations result in from conventional neuronal circuit study, this method has its own imperfections, such as optogenetic modulation of neural activity, using an internal, animal-generated, light source. In this review, limitations of external light delivery systems and possible approaches for using internal light sources in laboratory animals and perhaps, human being, are being addressed. © 2016 Elsevier Inc.
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