Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Neutrophil to Lymphocyte Ratio and C-Reactive Protein Level As Prognostic Markers in Mild Versus Severe Covid-19 Patients Publisher



Mousavinasab SD1, 2 ; Mardani R3 ; Azadani HN4 ; Zali F5 ; Vasmehjani AA4 ; Sabeti S6 ; Darazam IA7 ; Ahmadi N8
Authors
Show Affiliations
Authors Affiliations
  1. 1. Viral vaccine research center, Pasteur Institute of Iran, Tehran, Iran
  2. 2. Department of Research and Development, Production and Research Complex, Pasteur Institute, Tehran, Iran
  3. 3. Department of Biochemistry, Pasteur Institute of Iran, Tehran, Iran
  4. 4. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Science, Tehran, Iran
  6. 6. Pathology Ward, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Infectious Diseases and Tropical Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  8. 8. Proteomics Research Center, Department of Medical Lab Technology, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Gastroenterology and Hepatology from Bed to Bench Published:2020


Abstract

Aim: This research aimed to investigate neutrophil to lymphocyte ratio (NLR) with C-reactive protein to identify potential clinical predictors and analyze differences among severe and non-severe COVID-19 patients. Background: NLR and CRP are established markers that reflect systemic inflammatory, and these parameters alter in patients with novel coronavirus (SARS-CoV-2) pneumonia (COVID-19). Methods: A population of patients with COVID-19 referred to Loghman Hospital in Tehran was analyzed. The baseline data of laboratory examinations, including NLR and CRP levels, was collected. Pearson analysis was used to assess the independent relationship between the NLR with disease severity and CRP levels. Results: COVID-19 cases comprised 14 (20%) patients with severe disease and 56 (80%) with non-severe infection. The mean values of WBC, NEU, LYM, and NLR of the severe patients were significantly higher than those of the non-severe patients. Forty-six patients (65.7%) had NLR >1, and the remaining patients had NLR <1. Plasma CRP levels were higher in severe cases than in non-severe cases, and this difference was significant. The results showed that NLR was positively correlated with CRP levels (R=0.23) and negatively correlated with WBC (R=-0.38). CRP (AUC = 0.97, 95% CI: 0.95-0.99) and NLR (AUC = 0.87, 95% CI: 0.81-0.93) had very good accuracy in predicting the severity of COVID-19 disease. Conclusion: The findings of this study indicated that the integration of NLR and CRP may lead to improved predictions and is recommended as a valuable early marker to assess prognosis and evaluate the severity of clinical symptoms in COVID-19 patients. © 2020 RIGLD, Research Institute for Gastroenterology and Liver Diseases.
Related Docs
View other Related Docs
1. Biomarker Based Biosensors: An Opportunity for Diagnosis of Covid-19, Reviews in Medical Virology (2022)
2. Prognostic Value of Inflammatory Biomarkers for Predicting the Extent of Lung Involvement and Final Clinical Outcome in Patients With Covid-19, Journal of Research in Medical Sciences (2021)
3. Serum C-Reactive Protein Greater Than 75 Mg/Dl As an Early Available Laboratory Predictor of Severe Covid-19: A Systematic Review, Immunity# Inflammation and Disease (2023)
4. Pathological Effects of Sars-Cov-2 on Hematological and Immunological Cells: Alterations in Count, Morphology, and Function, Pathology Research and Practice (2022)
5. The Contributory Role of Lymphocyte Subsets, Pathophysiology of Lymphopenia and Its Implication As Prognostic and Therapeutic Opportunity in Covid-19, International Immunopharmacology (2021)
6. Association Between Serum Inflammatory Parameters and the Disease Severity in Covid-19 Patients, Journal of Clinical Laboratory Analysis (2022)
7. Natural Killer Cells in Covid-19: From Infection, to Vaccination and Therapy, Future Virology (2023)
8. A Review on an Ongoing Pandemic Caused by the Severe Acute Respiratory Syndrome Coronavirus 2: The Pathogenesis, Epidemiology, Immunological Features, and Currently Available Diagnostic Tests, Reviews and Research in Medical Microbiology (2022)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (4)
Hadiseh Hosamirudsari (4)
Other Related Docs
9. Cancer Care Management During the Covid-19 Pandemic, Risk Management and Healthcare Policy (2020)
10. Evaluation of the Relationship Between Serum Bdnf Concentration and Indicators of Oxidative Stress and Inflammation in Covid-19 Patients With Neurological Disorders - a Pilot Study, Neurological Research (2023)
11. Central Nervous System Manifestations in Covid-19 Patients: A Systematic Review and Meta-Analysis, Brain and Behavior (2021)
12. A Possible Pathogenic Correlation Between Neutrophil Elastase (Ne) Enzyme and Inflammation in the Pathogenesis of Coronavirus Disease 2019 (Covid-19), International Immunopharmacology (2021)
13. Can Anti-Parasitic Drugs Help Control Covid-19?, Future Virology (2022)
14. Can Laboratory Tests at the Time of Admission Guide Us to the Prognosis of Patients With Covid-19?, Journal of Preventive Medicine and Hygiene (2021)
15. Cytokine Storm in the Pathophysiology of Covid-19: Possible Functional Disturbances of Mirnas, International Immunopharmacology (2021)
16. Review on Oxidative Stress Relation on Covid-19: Biomolecular and Bioanalytical Approach, International Journal of Biological Macromolecules (2021)
17. Molecular Signaling Pathways, Pathophysiological Features in Various Organs, and Treatment Strategies in Sars-Cov2 Infection, Acta Histochemica (2022)
18. Corona Virus Disease 2019 (Covid-19) As a System-Level Infectious Disease With Distinct Sex Disparities, Frontiers in Immunology (2021)
19. Neutrophil to Lymphocyte Ratio (Nlr) and Derived Nlr Combination: A Cost-Effective Predictor of Moderate to Severe Covid-19 Progression, Iranian Journal of Allergy# Asthma and Immunology (2022)
20. The Role of Lovastatin in the Attenuation of Covid-19, International Immunopharmacology (2021)
21. Novel Systemic Inflammation Markers to Predict Covid-19 Prognosis, Frontiers in Immunology (2021)
22. The Evaluation of Hematological Parameters and Their Correlation With Disease Prognosis in Covid-19 Disease in Iran, International Journal of Hematology-Oncology and Stem Cell Research (2023)
23. The Impact of Covid-19 on Diagnostic Biomarkers in Neuropsychiatric and Neuroimmunological Diseases: A Review, Reviews in the Neurosciences (2022)
24. A Possible Pathogenic Role of Syndecan-1 in the Pathogenesis of Coronavirus Disease 2019 (Covid-19), International Immunopharmacology (2021)
25. Covid-19 and Multiorgan Failure: A Narrative Review on Potential Mechanisms, Journal of Molecular Histology (2020)
26. Metabolomics Signatures of Sars-Cov-2 Infection, Advances in Experimental Medicine and Biology (2022)
27. A Randomized Controlled Clinical Trial on Efficacy and Safety of Anakinra in Patients With Severe Covid-19, Immunity# Inflammation and Disease (2022)
28. Cancer and Coronavirus Disease (Covid-19): Comorbidity, Mechanical Ventilation, and Death Risk, Journal of Gastrointestinal Cancer (2021)
29. Clinical Symptoms and Types of Samples Are Critical Factors for the Molecular Diagnosis of Symptomatic Covid-19 Patients: A Systematic Literature Review, International Journal of Microbiology (2021)
30. Covid-19 Outcomes in Kidney Transplant Recipients Receiving a Combination of Sofosbuvir-Daclatasvir Treatment; a Single-Center Study, Journal of Renal Injury Prevention (2023)
31. Investigating How Interleukin 6 Serum Level, Blood Group Type, and Underlying Diseases Are Associated in Patients Admitted to the Covid-19 Intensive Care Unit: A Retrospective Study, Open Public Health Journal (2023)
32. The Coronavirus Disease 2019 and Effect on Liver Function: A Hidden and Vital Interaction Beyond the Respiratory System, Reviews and Research in Medical Microbiology (2022)
33. A Review on Headaches Due to Covid-19 Infection, Frontiers in Neurology (2022)
34. Clinical and Radiologic Characteristics of Covid-19 in Patients With Ckd, Iranian Journal of Kidney Diseases (2020)
35. Covid-19 Infection in Heart Transplant Recipients: Results of a Six-Month Prospective Survey-Based Study, Acta Medica Iranica (2022)
36. Auxiliary Role of Mesenchymal Stem Cells As Regenerative Medicine Soldiers to Attenuate Inflammatory Processes of Severe Acute Respiratory Infections Caused by Covid-19, Cell and Tissue Banking (2020)
37. Differential Antibody Response to Sars-Cov-2 Antigens in Recovered and Deceased Iranian Covid-19 Patients, Viral Immunology (2021)
38. Vitamin D Supplementation and Calcium: Many-Faced Gods or Nobody in Fighting Against Corona Virus Disease 2019, Clinical Nutrition ESPEN (2024)
39. Demographics, Laboratory Parameters and Outcomes of 1061 Patients With Coronavirus Disease 2019: A Report From Tehran, Iran, New Microbes and New Infections (2020)
40. Tocilizumab in Icu-Admitted Covid-19 Patients: A Retrospective Study, Medical Journal of the Islamic Republic of Iran (2023)
41. Covid-19 Clinical Manifestations and Treatment Strategies Among Solid-Organ Recipients: A Systematic Review of Cases, Transplant Infectious Disease (2020)
42. Pathogenesis, Clinical Manifestations and Complications of Coronavirus Disease 2019 (Covid-19), Future Microbiology (2020)
43. Th17 and Treg Cells Function in Sars-Cov2 Patients Compared With Healthy Controls, Journal of Cellular Physiology (2021)
44. Diabetes As One of the Long-Term Covid-19 Complications: From the Potential Reason of More Diabetic Patients’ Susceptibility to Covid-19 to the Possible Caution of Future Global Diabetes Tsunami, Inflammopharmacology (2023)
45. Immunosenescence and Inflamm-Ageing in Covid-19, Ageing Research Reviews (2023)
46. Comparison of Clinical Manifestation and Mortality-Related Risk Factors Between Elderly and Middle-Aged Covid-19 Patients, Acta Medica Iranica (2023)
47. Recent Findings on the Coronavirus Disease 2019 (Covid-19); Immunopathogenesis and Immunotherapeutics, International Immunopharmacology (2020)
48. Pathophysiology of Covid-19 Infection: What Is the Novel Coronavirus (Sars-Cov-2) Doing to Body? a Comprehensive Systematic Review, Reviews and Research in Medical Microbiology (2021)
49. Correlation of Clinical, Laboratory, and Short-Term Outcomes of Immunocompromised and Immunocompetent Covid-19 Patients With Semi-Quantitative Chest Ct Score Findings: A Case-Control Study, Immunity# Inflammation and Disease (2024)
50. Risk Factors for Adverse Outcomes of Covid-19 Patients: Possible Basis for Diverse Responses to the Novel Coronavirus Sars-Cov-2, Life Sciences (2021)