Stimulation of Neurotrophic Factors and Inhibition of Proinflammatory Cytokines by Exogenous Application of Triiodothyronine in the Rat Model of Ischemic Stroke

Stimulation of Neurotrophic Factors and Inhibition of Proinflammatory Cytokines by Exogenous Application of Triiodothyronine in the Rat Model of Ischemic Stroke Publisher Pubmed

Sabbaghziarani F¹ ; Mortezaee K² ; Akbari M³ ; Kashani IR³ ; Soleimani M^{4, 5} ; Hassanzadeh G³ ; Zendedel A^{6, 7}

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1. Department of Anatomy, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
2. Department of Anatomy, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
3. Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
4. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
5. Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
6. Institute of Neuroanatomy, RWTH Aachen University, Aachen, Germany
7. Department of Anatomical Sciences, Faculty of Medicine, Giulan University of Medical Sciences, Rasht, Iran

Source: Cell Biochemistry and Function Published:2017

Abstract

There is a positive relation between decreases of triiodothyronine (T3) amounts and severity of stroke. The aim of this study was to evaluate the effect of exogenous T3 application on levels of neurogenesis markers in the subventricular zone. Cerebral ischemia was induced by middle cerebral artery occlusion in male Wistar rats. There were 4 experimental groups: sham, ischemic, vehicle, and treatment. Rats were injected with T3 (25 μg/kg, IV injection) at 24 hours after ischemia. Animals were sacrificed at day 7 after ischemia. There were high levels of brain-derived neurotrophic factor, nestin, and Sox2 expressions in gene and protein levels in the T3 treatment group (P ≤.05 vs ischemic group). Treatment group showed high levels of sera T3 and thyroxine (T4) but low levels of thyrotropin (TSH), tumor necrosis factor-α, and interleukin-6 (P ≤.05 vs ischemic group) at day 4 after ischemia induction. Findings of this study revealed the effectiveness of exogenous T3 application in the improvement of neurogenesis possibly via regulation of proinflammatory cytokines. Copyright © 2017 John Wiley & Sons, Ltd.

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Iraj Ragerdi Kashani (1)

Gholamreza Hassanzadeh (1)

Style	Citing Format
MLA	Sabbaghziarani F, et al.. "Stimulation of Neurotrophic Factors and Inhibition of Proinflammatory Cytokines by Exogenous Application of Triiodothyronine in the Rat Model of Ischemic Stroke." Cell Biochemistry and Function, vol. 35, no. 1, 2017, pp. 50-55.
APA	Sabbaghziarani F, Mortezaee K, Akbari M, Kashani IR, Soleimani M, Hassanzadeh G, Zendedel A (2017). Stimulation of Neurotrophic Factors and Inhibition of Proinflammatory Cytokines by Exogenous Application of Triiodothyronine in the Rat Model of Ischemic Stroke. Cell Biochemistry and Function, 35(1), 50-55.
Chicago	Sabbaghziarani F, Mortezaee K, Akbari M, Kashani IR, Soleimani M, Hassanzadeh G, Zendedel A. "Stimulation of Neurotrophic Factors and Inhibition of Proinflammatory Cytokines by Exogenous Application of Triiodothyronine in the Rat Model of Ischemic Stroke." Cell Biochemistry and Function 35, no. 1 (2017): 50-55.
Harvard	Sabbaghziarani F et al. (2017) 'Stimulation of Neurotrophic Factors and Inhibition of Proinflammatory Cytokines by Exogenous Application of Triiodothyronine in the Rat Model of Ischemic Stroke', Cell Biochemistry and Function, 35(1), pp. 50-55.
Vancouver	Sabbaghziarani F, Mortezaee K, Akbari M, Kashani IR, Soleimani M, Hassanzadeh G, et al.. Stimulation of Neurotrophic Factors and Inhibition of Proinflammatory Cytokines by Exogenous Application of Triiodothyronine in the Rat Model of Ischemic Stroke. Cell Biochemistry and Function. 2017;35(1):50-55.
BibTex	@article{ author = {Sabbaghziarani F and Mortezaee K and Akbari M and Kashani IR and Soleimani M and Hassanzadeh G and Zendedel A}, title = {Stimulation of Neurotrophic Factors and Inhibition of Proinflammatory Cytokines by Exogenous Application of Triiodothyronine in the Rat Model of Ischemic Stroke}, journal = {Cell Biochemistry and Function}, volume = {35}, number = {1}, pages = {50-55}, year = {2017} }
RIS	TY - JOUR AU - Sabbaghziarani F AU - Mortezaee K AU - Akbari M AU - Kashani IR AU - Soleimani M AU - Hassanzadeh G AU - Zendedel A TI - Stimulation of Neurotrophic Factors and Inhibition of Proinflammatory Cytokines by Exogenous Application of Triiodothyronine in the Rat Model of Ischemic Stroke JO - Cell Biochemistry and Function VL - 35 IS - 1 SP - 50 EP - 55 PY - 2017 ER -

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