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The Open, Randomized, Positive Control Clinical Trial of Guluronic Acid (G2013) on Sars-Cov-2 Patients Publisher Pubmed



Aghazadeh Z1 ; Delir DS2 ; Gholamrezaie HR2 ; Sadoughi A1 ; Asl AN3 ; Sanami MN2 ; Gorabi AM3, 4 ; Panahi Y5 ; Taeb M1 ; Razavi A1 ; Rafia S1 ; Naderiyan Z2 ; Robatjazi B1 ; Mirshafiey A1
Authors
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Authors Affiliations
  1. 1. Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Farhikhtegan Hospital, Tehran, Iran
  3. 3. Health Re-search Center, Chamran Hospital, Tehran, Iran
  4. 4. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Deputy for Research and Technology, Ministry of Health and Medical Education, Tehran, Iran

Source: Current Drug Discovery Technologies Published:2023


Abstract

Introduction: Recently, the coronavirus disease 2019 (COVID-19) infection, with a vast spectrum of clinical and paraclinical symptoms has been a major health concern worldwide. Therapeutical management of COVID-19 includes antiviral and anti-inflammatory drugs. NSAIDs, as the second-line therapy, are often prescribed to relieve the symptoms of COVID-19. The a-L-guluronic acid (G2013) is a non-steroidal patented (PCT/EP2017/067920) agent with immunomodulatory properties. This study investigated the effect of G2013 on the outcome of COVID-19 in moderate to severe patients. Methods: The disease’s symptoms were followed up during hospitalization and for 4 weeks postdischarge in G2013 and control groups. Paraclinical indices were tested at the time of admission and discharge. Statistical analysis was performed on clinical and paraclinical parameters and ICU admission and death rate. Results: The primary and secondary outcomes indicated the efficiency of G2013 on COVID-19 patients’ management. There were significant differences in the duration of improvement of fever, coughing, fatigue/malaise. Also, a comparison of paraclinical indices at the time of admission and discharge showed significant change in prothrombin, D-dimer, and platelet. As the main findings of this study, G2013 significantly decreased the percentage of ICU admission (control:17 patients, G2013:1 patient) and death (control: 7 cases, G2013:0). Conclusion: These results conclude that G2013 has sufficient potential to be considered for moderate to severe COVID-19 patients, can significantly reduce the clinical and physical complications of this disease, has a positive effect on modulating the coagulopathy process, and aids in saving lives. Clinical Trial Registration Number: IR.CHAMRANHOSPITAL.REC.1399.003, and IRCT200809010 © 2023 Bentham Science Publishers.
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