Traditional Dry Cupping Therapy Versus Medroxyprogesterone Acetate in the Treatment of Idiopathic Menorrhagia: A Randomized Controlled Trial Publisher



Azizkhani M¹ ; Vahid Dastjerdi M² ; Tabaraee Arani M¹ ; Pirjani R³ ; Sepidarkish M⁴ ; Ghorat F⁵ ; Karimi M¹
Source: Iranian Red Crescent Medical Journal Published:2018

Abstract

Background: Dry cupping has been used as a treatment for abnormal uterine bleeding in Iranian traditional medicine. Objectives: The present study aimed at evaluating the usefulness of dry cupping on excessive menstrual blood loss in menorrhagia with a well- validated menstrual pictogram compared to medroxyprogesterone acetate. Methods: A total of 162 women with menorrhagia were enrolled in this prospective, randomized, controlled trial in Iran from 2015 to 2016. Written informed consent was obtained, then, patients were randomly allocated into dry cupping (3 sessions of interrupted and kinetic dry cupping during menstrual bleeding) or medroxyprogesterone acetate (10 mg/day throughout the luteal period) groups using a random number sequence. The number of bleeding days and objective estimation of menstrual blood loss using a pictorial blood loss assessment chart (PBAC) were recorded before the intervention and at specific intervals (1 and 3 months post-intervention). Results: At 1 and 3 months, PBAC scores were significantly lower in women treated with cupping compared with women treated with medroxyprogesterone acetate. These reductions in PBAC score were 214.9 mL with 95% CI (120.5 to 309.2) greater than medroxyprogesterone acetate at 1 month and 237.3 with 95% CI (143.0 to 331.7) at 3- month follow- up period. Reduction in the number of bleeding days in the cupping group for almost one day was better than the control groups at 1 and 3 months follow- up (Mean difference:-1.03, 95% CI (-1.78 to -0.26), P = 0.007). Conclusions: Dry cupping is an effective treatment in reducing the intensity of bleeding during the menstrual period compared to medroxyprogesterone acetate. © 2018, Iranian Red Crescent Medical Journal.