Copper-Catalyzed Four-Component Synthesis of Imidazo[1,2-A]Pyridines Via Sequential Reductive Amination, Condensation, and Cyclization

Copper-Catalyzed Four-Component Synthesis of Imidazo[1,2-A]Pyridines Via Sequential Reductive Amination, Condensation, and Cyclization Publisher

Allahabadi E¹ ; Ebrahimi S¹ ; Soheilizad M² ; Khoshneviszadeh M³ ; Mahdavi M¹

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1. Drug Design and Development Research Center, Tehran University of Medical Science, Tehran, 14176, Iran
2. School of Chemistry, College of Science, University of Tehran, PO Box 14155-6455, Tehran, Iran
3. Medicinal & Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Source: Tetrahedron Letters Published:2017

Abstract

A novel and efficient four-component approach for the synthesis of 2,3-disubstituted imidazo[1,2-a]pyridines is described. The copper-catalyzed reductive amination of 2-bromopyridine by sodium azide followed by sequential condensation and cyclization with aldehydes and isocyanides afforded the corresponding imidazo[1,2-a]pyridines in good yields. © 2016 Elsevier Ltd

Style	Citing Format
MLA	Allahabadi E, et al.. "Copper-Catalyzed Four-Component Synthesis of Imidazo[1,2-A]Pyridines Via Sequential Reductive Amination, Condensation, and Cyclization." Tetrahedron Letters, vol. 58, no. 2, 2017, pp. 121-124.
APA	Allahabadi E, Ebrahimi S, Soheilizad M, Khoshneviszadeh M, Mahdavi M (2017). Copper-Catalyzed Four-Component Synthesis of Imidazo[1,2-A]Pyridines Via Sequential Reductive Amination, Condensation, and Cyclization. Tetrahedron Letters, 58(2), 121-124.
Chicago	Allahabadi E, Ebrahimi S, Soheilizad M, Khoshneviszadeh M, Mahdavi M. "Copper-Catalyzed Four-Component Synthesis of Imidazo[1,2-A]Pyridines Via Sequential Reductive Amination, Condensation, and Cyclization." Tetrahedron Letters 58, no. 2 (2017): 121-124.
Harvard	Allahabadi E et al. (2017) 'Copper-Catalyzed Four-Component Synthesis of Imidazo[1,2-A]Pyridines Via Sequential Reductive Amination, Condensation, and Cyclization', Tetrahedron Letters, 58(2), pp. 121-124.
Vancouver	Allahabadi E, Ebrahimi S, Soheilizad M, Khoshneviszadeh M, Mahdavi M. Copper-Catalyzed Four-Component Synthesis of Imidazo[1,2-A]Pyridines Via Sequential Reductive Amination, Condensation, and Cyclization. Tetrahedron Letters. 2017;58(2):121-124.
BibTex	@article{ author = {Allahabadi E and Ebrahimi S and Soheilizad M and Khoshneviszadeh M and Mahdavi M}, title = {Copper-Catalyzed Four-Component Synthesis of Imidazo[1,2-A]Pyridines Via Sequential Reductive Amination, Condensation, and Cyclization}, journal = {Tetrahedron Letters}, volume = {58}, number = {2}, pages = {121-124}, year = {2017} }
RIS	TY - JOUR AU - Allahabadi E AU - Ebrahimi S AU - Soheilizad M AU - Khoshneviszadeh M AU - Mahdavi M TI - Copper-Catalyzed Four-Component Synthesis of Imidazo[1,2-A]Pyridines Via Sequential Reductive Amination, Condensation, and Cyclization JO - Tetrahedron Letters VL - 58 IS - 2 SP - 121 EP - 124 PY - 2017 ER -

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