Synthesis and Structure-Activity Relationship Study of Benzofuran-Based Chalconoids Bearing Benzylpyridinium Moiety As Potent Acetylcholinesterase Inhibitors

Synthesis and Structure-Activity Relationship Study of Benzofuran-Based Chalconoids Bearing Benzylpyridinium Moiety As Potent Acetylcholinesterase Inhibitors Publisher Pubmed

Mostofi M¹ ; Mohammadi Ziarani G¹ ; Mahdavi M² ; Moradi A³ ; Nadri H³ ; Emami S⁴ ; Alinezhad H⁵ ; Foroumadi A² ; Shafiee A²

Show Affiliations

1. Department of Chemistry, Alzahra University, Vanak Square, Tehran, Iran
2. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medicinal Sciences, Tehran, Iran
3. Department of Medicinal Chemistry, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
4. Department of Medicinal Chemistry, Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
5. Faculty of Chemistry, University of Mazandaran, Babolsar, Iran

Source: European Journal of Medicinal Chemistry Published:2015

Abstract

A series of benzofuran-based chalconoids 6a-v were designed and synthesized as new potential AChE inhibitors. The in vitro assay of synthesized compounds 6a-v showed that most compounds had significant anti-AChE activity at micromolar or sub-micromolar levels. Among the tested compounds, 3-pyridinium derivative 6m bearing N-(2-bromobenzyl) moiety and 7-methoxy substituent on the benzofuran ring exhibited superior activity. This compound with IC50 value of 0.027 μM was as potent as standard drug donepezil. © 2015 Elsevier Masson SAS. All rights reserved.

Style	Citing Format
MLA	Mostofi M, et al.. "Synthesis and Structure-Activity Relationship Study of Benzofuran-Based Chalconoids Bearing Benzylpyridinium Moiety As Potent Acetylcholinesterase Inhibitors." European Journal of Medicinal Chemistry, vol. 103, no. , 2015, pp. 361-369.
APA	Mostofi M, Mohammadi Ziarani G, Mahdavi M, Moradi A, Nadri H, Emami S, Alinezhad H, Foroumadi A, Shafiee A (2015). Synthesis and Structure-Activity Relationship Study of Benzofuran-Based Chalconoids Bearing Benzylpyridinium Moiety As Potent Acetylcholinesterase Inhibitors. European Journal of Medicinal Chemistry, 103(), 361-369.
Chicago	Mostofi M, Mohammadi Ziarani G, Mahdavi M, Moradi A, Nadri H, Emami S, Alinezhad H, Foroumadi A, Shafiee A. "Synthesis and Structure-Activity Relationship Study of Benzofuran-Based Chalconoids Bearing Benzylpyridinium Moiety As Potent Acetylcholinesterase Inhibitors." European Journal of Medicinal Chemistry 103, no. (2015): 361-369.
Harvard	Mostofi M et al. (2015) 'Synthesis and Structure-Activity Relationship Study of Benzofuran-Based Chalconoids Bearing Benzylpyridinium Moiety As Potent Acetylcholinesterase Inhibitors', European Journal of Medicinal Chemistry, 103(), pp. 361-369.
Vancouver	Mostofi M, Mohammadi Ziarani G, Mahdavi M, Moradi A, Nadri H, Emami S, et al.. Synthesis and Structure-Activity Relationship Study of Benzofuran-Based Chalconoids Bearing Benzylpyridinium Moiety As Potent Acetylcholinesterase Inhibitors. European Journal of Medicinal Chemistry. 2015;103():361-369.
BibTex	@article{ author = {Mostofi M and Mohammadi Ziarani G and Mahdavi M and Moradi A and Nadri H and Emami S and Alinezhad H and Foroumadi A and Shafiee A}, title = {Synthesis and Structure-Activity Relationship Study of Benzofuran-Based Chalconoids Bearing Benzylpyridinium Moiety As Potent Acetylcholinesterase Inhibitors}, journal = {European Journal of Medicinal Chemistry}, volume = {103}, number = {}, pages = {361-369}, year = {2015} }
RIS	TY - JOUR AU - Mostofi M AU - Mohammadi Ziarani G AU - Mahdavi M AU - Moradi A AU - Nadri H AU - Emami S AU - Alinezhad H AU - Foroumadi A AU - Shafiee A TI - Synthesis and Structure-Activity Relationship Study of Benzofuran-Based Chalconoids Bearing Benzylpyridinium Moiety As Potent Acetylcholinesterase Inhibitors JO - European Journal of Medicinal Chemistry VL - 103 IS - SP - 361 EP - 369 PY - 2015 ER -

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