The Phenotype of Mixed Connective Tissue Disease Patients Having Associated Interstitial Lung Disease

The Phenotype of Mixed Connective Tissue Disease Patients Having Associated Interstitial Lung Disease Publisher Pubmed

Boleto G^{1, 2} ; Reiseter S³ ; Hoffmannvold AM⁴ ; Mirouse A⁵ ; Cacoub P⁵ ; Matuccicerinic M^{6, 7} ; Silverioantonio M⁸ ; Fonseca JE⁸ ; Duarte AC⁹ ; Pestana Lopes J⁹ ; Riccieri V¹⁰ ; Lescoat A¹¹ ; Le Tallec E¹¹ ; Castellvi Barranco I¹² Show All Authors

Boleto G^{1, 2}
Reiseter S³
Hoffmannvold AM⁴
Mirouse A⁵
Cacoub P⁵
Matuccicerinic M^{6, 7}
Silverioantonio M⁸
Fonseca JE⁸
Duarte AC⁹
Pestana Lopes J⁹
Riccieri V¹⁰
Lescoat A¹¹
Le Tallec E¹¹
Castellvi Barranco I¹²
Tandaipan JL¹²
Airo P¹³
Kuwana M¹⁴
Kavosi H¹⁵
Avouac J^{1, 16}
Allanore Y^{1, 16}

Show Affiliations

1. Department of Rheumatology, Universite Paris Cite, Cochin Hospital, Paris, France
2. Instituto Portugues de Reumatologia, Lisboa, Portugal
3. Department of Rheumatology, Martina Hansen Hospital, Sandvika, Norway
4. Department of Rheumatology, Oslo University Hospital, Oslo, Norway
5. Department of Internal Medicine and Clinical Immunology, Groupe Hospitalier Pitie-Salpetriere, AP-HP, Paris, F-75013, France
6. Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UNIRAR), Irccs San Raffaele Hospital, Milan, Italy
7. Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
8. Servico de Reumatologia e Doencas Osseas Metabolicas, Centro Hospitalar Universitario Lisboa Norte and Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Centro Academico de Medicina de Lisboa (CAML), Lisbon, Portugal
9. Servico de Reumatologia, Hospital Garcia de Orta, Almada, Portugal
10. Department of Clinical, Internal, Anaesthesiologic, Cardiologic Sciences, University of Rome Sapienza, Rome, Italy
11. Department of Internal Medicine and Clinical Immunology, Rennes University Hospital, Rennes, France
12. Department of Rheumatology and Systemic Autoimmune Diseases, Hospital Universitari de la Santa Creu i Sant Pau, Barcelona, Spain
13. Rheumatology and Clinical Immunology Unit, Spedali Civili, Brescia, Italy
14. Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan
15. Rheumatology Research Center, Shariati Hospital, Tehran University of Medical Sciences, Kargar Avenue, 14117-13137, Tehran, Iran
16. INSERM U1016, Institut Cochin, CNRS UMR8104, Paris, France

Source: Seminars in Arthritis and Rheumatism Published:2023

Abstract

Objective: We aimed to compare two matched populations of patients with MTCD with and without associated ILD and to identify predictive factors for ILD progression and severity. Methods: This international multicenter retrospective study (14 tertiary hospitals), included MCTD patients who fulfilled at least one historical MCTD classification criteria. ILD was defined by the presence of typical chest high-resolution computed tomography (HRCT) abnormalities. Factors associated with ILD were assessed at baseline. Long-term progressive ILD was assessed in MCTD-ILD patients with multiple forced vital capacity (FVC) measurements. Results: 300 patients with MCTD were included. Mean age at diagnosis was 39.7 ± 15.4 years and 191 (63.7%) were women. Mean follow-up was 7.8 ± 5.5 years. At baseline, we identified several factors associated with ILD presence: older age (p = 0.01), skin thickening (p = 0.03), upper gastro-intestinal (GI) symptoms (p<0.001), FVC <80% (p<0.0001), diffusing capacity for carbon monoxide <80% (p<0.0001), anti-topoisomerase antibodies (p = 0.01), SSA/Ro antibodies (p = 0.02), cryoglobulinemia (p = 0.04) and elevated C-reactive protein (p<0.001). Patients with MTCD-ILD were more likely to be treated with synthetic immunosuppressant agents (p<0.001) in particular mycophenolate mofetil (p = 0.03). Digital ulcers (DU) were identified as a risk factor for FVC decline >10%. During follow-up mortality was higher in the MTCD-ILD group (p<0.001). Conclusion: In this large international cohort of patients with MTCD, we identified different factors associated with ILD. Our findings also provide evidence that MCTD-ILD patients have increased mortality and that DU are associated with progressive lung disease. © 2023

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Style	Citing Format
MLA	Boleto G, et al.. "The Phenotype of Mixed Connective Tissue Disease Patients Having Associated Interstitial Lung Disease." Seminars in Arthritis and Rheumatism, vol. 63, no. , 2023, pp. -.
APA	Boleto G, Reiseter S, Hoffmannvold AM, Mirouse A, Cacoub P, Matuccicerinic M, Silverioantonio M, Fonseca JE, Duarte AC, Pestana Lopes J, Riccieri V, Lescoat A, Le Tallec E, Castellvi Barranco I, Tandaipan JL, Airo P, Kuwana M, Kavosi H, Avouac J, Allanore Y (2023). The Phenotype of Mixed Connective Tissue Disease Patients Having Associated Interstitial Lung Disease. Seminars in Arthritis and Rheumatism, 63(), -.
Chicago	Boleto G, Reiseter S, Hoffmannvold AM, Mirouse A, Cacoub P, Matuccicerinic M, Silverioantonio M, et al.. "The Phenotype of Mixed Connective Tissue Disease Patients Having Associated Interstitial Lung Disease." Seminars in Arthritis and Rheumatism 63, no. (2023): -.
Harvard	Boleto G et al. (2023) 'The Phenotype of Mixed Connective Tissue Disease Patients Having Associated Interstitial Lung Disease', Seminars in Arthritis and Rheumatism, 63(), pp. -.
Vancouver	Boleto G, Reiseter S, Hoffmannvold AM, Mirouse A, Cacoub P, Matuccicerinic M, et al.. The Phenotype of Mixed Connective Tissue Disease Patients Having Associated Interstitial Lung Disease. Seminars in Arthritis and Rheumatism. 2023;63():-.
BibTex	@article{ author = {Boleto G and Reiseter S and Hoffmannvold AM and Mirouse A and Cacoub P and Matuccicerinic M and Silverioantonio M and Fonseca JE and Duarte AC and Pestana Lopes J and Riccieri V and Lescoat A and Le Tallec E and Castellvi Barranco I and Tandaipan JL and Airo P and Kuwana M and Kavosi H and Avouac J and Allanore Y}, title = {The Phenotype of Mixed Connective Tissue Disease Patients Having Associated Interstitial Lung Disease}, journal = {Seminars in Arthritis and Rheumatism}, volume = {63}, number = {}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Boleto G AU - Reiseter S AU - Hoffmannvold AM AU - Mirouse A AU - Cacoub P AU - Matuccicerinic M AU - Silverioantonio M AU - Fonseca JE AU - Duarte AC AU - Pestana Lopes J AU - Riccieri V AU - Lescoat A AU - Le Tallec E AU - Castellvi Barranco I AU - Tandaipan JL AU - Airo P AU - Kuwana M AU - Kavosi H AU - Avouac J AU - Allanore Y TI - The Phenotype of Mixed Connective Tissue Disease Patients Having Associated Interstitial Lung Disease JO - Seminars in Arthritis and Rheumatism VL - 63 IS - SP - EP - PY - 2023 ER -

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