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Potential Efficacy of Lactobacillus Casei Ibrc_M10711 on Expression and Activity of Insulin Degrading Enzyme But Not Insulin Degradation Publisher Pubmed



Neyazi N1, 2 ; Mohammadi Farsani T1 ; Nouri Z1 ; Ghahremani MH3, 4 ; Khorramizadeh MR1, 5 ; Tajerian R6 ; Motevaseli E4, 7
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Authors Affiliations
  1. 1. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, International Campus, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Oncology, Kabul Medical University, Jamal Mena, Kabul, Afghanistan
  3. 3. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Biosensor Research Center, Endocrinilogy and Metabolism Molecular-Cellular Sciences Institute, EMRI, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Food Microbiology Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: In Vitro Cellular and Developmental Biology - Animal Published:2017


Abstract

Type 2 diabetes (T2D) is a condition with insufficient insulin production or in the setting of insulin resistance with many origins including intestinal microbiota-related molecular mechanism. Insulin-degrading enzyme (IDE) is responsible for insulin breakdown in various tissues and is known as a potential drug target for T2D. Here, we assessed the effects of cell-free supernatant (CFS) and UV-killed Lactobacillus casei IBRC_M10711 on IDE expression, IDE activity, and insulin degradation in Caco-2 cell line. It was found that CFS and UV-killed L. casei IBRC_M10711 led to lower expression of IDE. UV-killed L. casei IBRC_M10711 significantly inhibited IDE activity but CFS did not. Insulin degradation was affected with none of them. In conclusion, L. casei IBRC_M10711 is effective on IDE expression and its activity, but not on insulin degradation. Future studies are recommended to explore the effect of this probiotic on other substrates of IDE. © 2016, The Society for In Vitro Biology.
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Hanieh-Sadat Ejtahed (3)
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