Time Interval Between the Onset of Symptoms and Diagnosis of Multiple Sclerosis and the Influential Factors: A National Registry-Based Study

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Time Interval Between the Onset of Symptoms and Diagnosis of Multiple Sclerosis and the Influential Factors: A National Registry-Based Study Publisher Pubmed

Khodaie F¹ ; Moghadasi AN¹ ; Hosseinnataj A² ; Baghbanian SM³ ; Ashtari F⁴ ; Razazian N⁵ ; Poursadeghfard M⁶ ; Majdinasab N⁷ ; Hatamian H⁸ ; Hoseini S⁹ ; Nahayati MA¹⁰ ; Nabavi SM¹¹ ; Faraji F¹² ; Harirchian MH¹³ Show All Authors

Khodaie F¹
Moghadasi AN¹
Hosseinnataj A²
Baghbanian SM³
Ashtari F⁴
Razazian N⁵
Poursadeghfard M⁶
Majdinasab N⁷
Hatamian H⁸
Hoseini S⁹
Nahayati MA¹⁰
Nabavi SM¹¹
Faraji F¹²
Harirchian MH¹³
Mir NHN¹⁴
Moghadam NB¹⁵
Sharifipour E¹⁶
Bayati A¹⁷
Kamali H¹⁸
Mozhdehipanah H¹⁹
Jalali N²⁰
Abotorabizarchi M²¹
Kamyari N²²
Nikbakht R²
Azimi A¹
Navardi S¹
Heidari H¹
Sahraian MA¹
Eskandarieh S¹

Source: Clinical Neurology and Neurosurgery Published:2024

Abstract

Objective: The time to diagnosis of multiple sclerosis (MS) is of great importance for early treatment, thereby reducing the disability and burden of the disease. The purpose of this study was to determine the time from the onset of clinical symptoms to the diagnosis of MS and to evaluate the factors associated with a late diagnosis in Iranian MS patients. Methods: The present cross-sectional study was conducted on patients with MS who were registered in the National MS Registry System of Iran (NMSRI). Results: Overall, 23291 MS patients registered in 18 provinces of Iran were included in this study. The mean (standard deviation) interval between the onset of the disease and diagnosis of MS was 13.42 (32.40) months, and the median was one month. The diagnostic interval of 41.6% of patients was less than one month, and 14.8% of them had a one-month time to diagnosis. Patients with an age of onset below 18 years and those diagnosed after the age of 50 years had a longer time to diagnosis (P<0.001). Patients with primary progressive MS (PPMS) had the longest time to diagnose and those with relapsing-remitting MS (RRMS) had the shortest time (P<0.001). The results of negative binominal regression showed that the average rate of delay in diagnosis in women was 12% less than that in men. The average delay in diagnosis in patients with a positive family history of MS was 23% more than that in others. The rate of delay in the diagnosis of patients with PPMS and secondary progressive MS was 2.22 and 1.66 times higher, respectively, compared with RRMS. Conclusion: The findings of the present study revealed that more than half of the MS patients were diagnosed within a one-month interval from the symptom onset, which is an acceptable period. More attention should be paid to patients’ access to medical facilities and MS specialists. © 2024

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Style	Citing Format
MLA	Khodaie F, et al.. "Time Interval Between the Onset of Symptoms and Diagnosis of Multiple Sclerosis and the Influential Factors: A National Registry-Based Study." Clinical Neurology and Neurosurgery, vol. 239, no. , 2024, pp. -.
APA	Khodaie F, Moghadasi AN, Hosseinnataj A, Baghbanian SM, Ashtari F, Razazian N, Poursadeghfard M, Majdinasab N, Hatamian H, Hoseini S, Nahayati MA, Nabavi SM, Faraji F, Harirchian MH, Mir NHN, Moghadam NB, Sharifipour E, Bayati A, Kamali H, ... Eskandarieh S (2024). Time Interval Between the Onset of Symptoms and Diagnosis of Multiple Sclerosis and the Influential Factors: A National Registry-Based Study. Clinical Neurology and Neurosurgery, 239(), -.
Chicago	Khodaie F, Moghadasi AN, Hosseinnataj A, Baghbanian SM, Ashtari F, Razazian N, Poursadeghfard M, et al.. "Time Interval Between the Onset of Symptoms and Diagnosis of Multiple Sclerosis and the Influential Factors: A National Registry-Based Study." Clinical Neurology and Neurosurgery 239, no. (2024): -.
Harvard	Khodaie F et al. (2024) 'Time Interval Between the Onset of Symptoms and Diagnosis of Multiple Sclerosis and the Influential Factors: A National Registry-Based Study', Clinical Neurology and Neurosurgery, 239(), pp. -.
Vancouver	Khodaie F, Moghadasi AN, Hosseinnataj A, Baghbanian SM, Ashtari F, Razazian N, et al.. Time Interval Between the Onset of Symptoms and Diagnosis of Multiple Sclerosis and the Influential Factors: A National Registry-Based Study. Clinical Neurology and Neurosurgery. 2024;239():-.
BibTex	@article{ author = {Khodaie F and Moghadasi AN and Hosseinnataj A and Baghbanian SM and Ashtari F and Razazian N and Poursadeghfard M and Majdinasab N and Hatamian H and Hoseini S and Nahayati MA and Nabavi SM and Faraji F and Harirchian MH and Mir NHN and Moghadam NB and Sharifipour E and Bayati A and Kamali H and Mozhdehipanah H and Jalali N and Abotorabizarchi M and Kamyari N and Nikbakht R and Azimi A and Navardi S and Heidari H and Sahraian MA and Eskandarieh S}, title = {Time Interval Between the Onset of Symptoms and Diagnosis of Multiple Sclerosis and the Influential Factors: A National Registry-Based Study}, journal = {Clinical Neurology and Neurosurgery}, volume = {239}, number = {}, pages = {-}, year = {2024} }
RIS	TY - JOUR AU - Khodaie F AU - Moghadasi AN AU - Hosseinnataj A AU - Baghbanian SM AU - Ashtari F AU - Razazian N AU - Poursadeghfard M AU - Majdinasab N AU - Hatamian H AU - Hoseini S AU - Nahayati MA AU - Nabavi SM AU - Faraji F AU - Harirchian MH AU - Mir NHN AU - Moghadam NB AU - Sharifipour E AU - Bayati A AU - Kamali H AU - Mozhdehipanah H AU - Jalali N AU - Abotorabizarchi M AU - Kamyari N AU - Nikbakht R AU - Azimi A AU - Navardi S AU - Heidari H AU - Sahraian MA AU - Eskandarieh S TI - Time Interval Between the Onset of Symptoms and Diagnosis of Multiple Sclerosis and the Influential Factors: A National Registry-Based Study JO - Clinical Neurology and Neurosurgery VL - 239 IS - SP - EP - PY - 2024 ER -