Enantioselective Cyclization Reactions Involving 3-Isothiocyanato Oxindoles: Synthesis of Spirocycles

Enantioselective Cyclization Reactions Involving 3-Isothiocyanato Oxindoles: Synthesis of Spirocycles Publisher

Edareh MH ; Doraghi F ; Farahani A ; Ghasemi M ; Mahdavi M

Source: RSC Advances Published:2026

Abstract

Recently, 3-isothiocyanato oxindoles have been used in various asymmetric cascade cyclization reactions for the synthesis of biologically important spirocyclic compounds. As a powerful and versatile ambiphilic synthon, 3-isothiocyanato oxindoles react effectively with diverse electron-deficient unsaturated bonds through Michael addition/cyclization reactions under organocatalysis or metal catalysis systems. This review highlights catalytic enantioselective cyclization reaction of 3-isothiocyanato oxindoles since 2011, and discusses their mechanistic insights. This journal is © The Royal Society of Chemistry, 2026.

Style	Citing Format
MLA	Edareh MH, et al.. "Enantioselective Cyclization Reactions Involving 3-Isothiocyanato Oxindoles: Synthesis of Spirocycles." RSC Advances, vol. 16, no. 29, 2026, pp. 26639-26658.
APA	Edareh MH, Doraghi F, Farahani A, Ghasemi M, Mahdavi M (2026). Enantioselective Cyclization Reactions Involving 3-Isothiocyanato Oxindoles: Synthesis of Spirocycles. RSC Advances, 16(29), 26639-26658.
Chicago	Edareh MH, Doraghi F, Farahani A, Ghasemi M, Mahdavi M. "Enantioselective Cyclization Reactions Involving 3-Isothiocyanato Oxindoles: Synthesis of Spirocycles." RSC Advances 16, no. 29 (2026): 26639-26658.
Harvard	Edareh MH et al. (2026) 'Enantioselective Cyclization Reactions Involving 3-Isothiocyanato Oxindoles: Synthesis of Spirocycles', RSC Advances, 16(29), pp. 26639-26658.
Vancouver	Edareh MH, Doraghi F, Farahani A, Ghasemi M, Mahdavi M. Enantioselective Cyclization Reactions Involving 3-Isothiocyanato Oxindoles: Synthesis of Spirocycles. RSC Advances. 2026;16(29):26639-26658.
BibTex	@article{ author = {Edareh MH and Doraghi F and Farahani A and Ghasemi M and Mahdavi M}, title = {Enantioselective Cyclization Reactions Involving 3-Isothiocyanato Oxindoles: Synthesis of Spirocycles}, journal = {RSC Advances}, volume = {16}, number = {29}, pages = {26639-26658}, year = {2026} }
RIS	TY - JOUR AU - Edareh MH AU - Doraghi F AU - Farahani A AU - Ghasemi M AU - Mahdavi M TI - Enantioselective Cyclization Reactions Involving 3-Isothiocyanato Oxindoles: Synthesis of Spirocycles JO - RSC Advances VL - 16 IS - 29 SP - 26639 EP - 26658 PY - 2026 ER -

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