Changing Correlations Among Adma, No and Hs-Crp in Normoalbuminuric and Microalbuminuric Patients With Type 2 Diabetes Publisher



Davoudi Z¹ ; Salehi SS¹ ; Larry M¹ ; Mirmiranpour H^{1, 2} ; Nargesi AA¹ ; Besharati S¹ ; Rabizadeh S¹ ; Esteghamati A¹ ; Nakhjavani M¹ Show Affiliations
Source: Meta Gene Published:2016

Abstract

Background Albuminuria is one of the first asymptomatic clinical manifestations of microvascular damage in type 2 diabetes. High-sensitivity C-reactive protein (hs-CRP), Asymmetric dimethylarginine (ADMA), and nitric oxide (NO) are important risk factors for endothelial dysfunction. The aim of this study is to evaluate hs-CRP, ADMA, and NO levels and their correlations in patients with type 2 diabetes respect to their albuminuric states. Methods We quantified serum hs-CRP, ADMA, and NO levels in 40 microalbuminuric (urinary albumin excretion ≤ 30 mg/day and < 300 mg/day) type 2 diabetic patients and 40 age, gender, and body mass index (BMI)-matched normoalbuminuric (urinary albumin excretion < 30 mg/day) diabetic patients in this case-control study. Results The mean value of albuminuria was 238 ± 58 mg/day in the microalbuminuric group and 12.6 ± 4.7 mg/day in the normoalbuminuric group. Creatinine was significantly higher and GFR was significantly lower in group with microalbuminuria than normoalbuminuria (p < 0.05). Albuminuric diabetic patients had significantly higher hs-CRP levels as compared to normoalbuminuric group (3.9 ± 0.8 mg/dL versus 5.7 ± 1.4 mg/dL, p < 0.05). However there were no significant differences in ADMA and NO between two groups but the ADMA/NO ratio was significantly higher in albuminuric group comparing with normoalbuminuric one (0.017 vs. 0.015, p value < 0.05). In control group (normoalbuminuria) age, gender and BMI-adjusted ADMA indicated a significant and positive correlation with NO (r = 0.430, p value = 0.022) and with hs-CRP (r = 0.362, p value = 0.041), and also a significant and positive correlation was found between hs-CRP and NO in case group (with microalbuminuria) (r = 0.370, p value = 0.026). Conclusion Hs-CRP was higher in microalbuminuric patients with type 2 diabetes compare to normoalbuminuric group. Also we found changing association among ADMA, NO and hs-CRP from normoalbuminuric to albuminuric state which this finding may be linked to the role of basic inflammation in confounding some interactions and creating some new ones. © 2016