1, 5-Dicaffeoylquinic Acid, an Α-Glucosidase Inhibitor From the Root of Dorema Ammoniacum D. Don

1, 5-Dicaffeoylquinic Acid, an Α-Glucosidase Inhibitor From the Root of Dorema Ammoniacum D. Don Publisher

Etemaditajbakhsh N¹ ; Faramarzi MA² ; Delnavazi MR¹

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1. Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Medicinal Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Research in Pharmaceutical Sciences Published:2020

Abstract

Dorema ammoniacum D. Don (Apiaceae family) is a perennial plant whose oleogum resin is used as a natural remedy for various diseases, especially chronic bronchitis, and asthma. In the present study, hydromethanolic extract of D. ammoniacum root was subjected to phytochemical analyses and a-glucosidase inhibitory potentials of the isolated compounds were assessed. Experimental approach: Silica gel (normal and reversed phases) and Sephadex LH-20 column chromatographies were used for the isolation and purification of the compounds. Structures of the compounds were characterized by 1D and 2D nuclear magnetic resonance (NMR) techniques. All the isolated compounds were assessed for their in vitro a-glucosidase inhibitory activity in comparison with acarbose, a standard drug. Findings/Results: Two phloroacetophenone glycosides; echisoside (1) and pleoside (2), along with dihydroferulic acid-4-O-b-D-glucopyranoside (3), and b-resorcylic acid (4), and two caffeoylquinic acid derivatives; chlorogenic acid (5) and 1, 5-dicaffeoylquinic acid (cynarin, 6) were isolated.Among the isolated compounds, the a-glucosidase inhibitory effect of 1,5-dicaffeoylquinic acid was found as 76.9% of the acarbose activity at 750 uM (IC50 value of acarbose). Conclusion and implications: Considerable a-glucosidase inhibitory effect of 1,5-dicaffeoylquinic acid makes it an appropriate candidate for further studies in the development of new natural antidiabetic drugs. © 2020 Wolters Kluwer Medknow Publications. All rights reserved.

2. Azerosides a and B: Two New Phloroacetophenone Glycosides From the Roots of Dorema Glabrum Fisch. & C.A. Mey, Medicinal Chemistry Research (2015)

3. Phytochemical and Antioxidant Investigation of the Aerial Parts of Dorema Glabrum Fisch. & C.A. Mey, Iranian Journal of Pharmaceutical Research (2015)

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Style	Citing Format
MLA	Etemaditajbakhsh N, Faramarzi MA, Delnavazi MR. "1, 5-Dicaffeoylquinic Acid, an Α-Glucosidase Inhibitor From the Root of Dorema Ammoniacum D. Don." Research in Pharmaceutical Sciences, vol. 15, no. 5, 2020, pp. 429-436.
APA	Etemaditajbakhsh N, Faramarzi MA, Delnavazi MR (2020). 1, 5-Dicaffeoylquinic Acid, an Α-Glucosidase Inhibitor From the Root of Dorema Ammoniacum D. Don. Research in Pharmaceutical Sciences, 15(5), 429-436.
Chicago	Etemaditajbakhsh N, Faramarzi MA, Delnavazi MR. "1, 5-Dicaffeoylquinic Acid, an Α-Glucosidase Inhibitor From the Root of Dorema Ammoniacum D. Don." Research in Pharmaceutical Sciences 15, no. 5 (2020): 429-436.
Harvard	Etemaditajbakhsh N, Faramarzi MA, Delnavazi MR (2020) '1, 5-Dicaffeoylquinic Acid, an Α-Glucosidase Inhibitor From the Root of Dorema Ammoniacum D. Don', Research in Pharmaceutical Sciences, 15(5), pp. 429-436.
Vancouver	Etemaditajbakhsh N, Faramarzi MA, Delnavazi MR. 1, 5-Dicaffeoylquinic Acid, an Α-Glucosidase Inhibitor From the Root of Dorema Ammoniacum D. Don. Research in Pharmaceutical Sciences. 2020;15(5):429-436.
BibTex	@article{ author = {Etemaditajbakhsh N and Faramarzi MA and Delnavazi MR}, title = {1, 5-Dicaffeoylquinic Acid, an Α-Glucosidase Inhibitor From the Root of Dorema Ammoniacum D. Don}, journal = {Research in Pharmaceutical Sciences}, volume = {15}, number = {5}, pages = {429-436}, year = {2020} }
RIS	TY - JOUR AU - Etemaditajbakhsh N AU - Faramarzi MA AU - Delnavazi MR TI - 1, 5-Dicaffeoylquinic Acid, an Α-Glucosidase Inhibitor From the Root of Dorema Ammoniacum D. Don JO - Research in Pharmaceutical Sciences VL - 15 IS - 5 SP - 429 EP - 436 PY - 2020 ER -

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