Investigation of Some Anaerobic Bacteria in the Sputum of Cystic Fibrosis Patients and Healthy People in Tehran, Iran

Investigation of Some Anaerobic Bacteria in the Sputum of Cystic Fibrosis Patients and Healthy People in Tehran, Iran

Hamayeli H¹ ; Abdiali A² ; Attaran B¹ ; Shafiei M² ; Modaresi M^{3, 4}

Show Affiliations

1. Department of Microbiology, Faculty of Biological Sciences, Alzahra University, Tehran, 1993893973, Iran
2. Department of Bacteriology, Pasteur Institute of Iran, Tehran, 1316943551, Iran
3. Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, 1416753955, Iran
4. Pediatric Pulmonary Disease and Sleep Medicine Research Center, Pediatric Centre of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, 1416753955, Iran

Source: Journal of Krishna Institute of Medical Sciences University Published:2024

Abstract

Background: In Cystic Fibrosis (CF) patients, increased mucus secretion and accumulation due to genetic defect leads to decreased oxygen levels and colonization of anaerobic bacteria. Aim and Objectives: In addition to investigating the difference in the prevalence of anaerobic bacteria in the sputum samples of CF patients and healthy populations, this study evaluated the relationship of demographic factors with anaerobic bacteria and CF disease. Material and Methods: Anaerobic bacteria were investigated in sputum samples of CF patients (50 people) and healthy individuals (18 people) in Tehran, Iran by molecular method in 2021-2022. The prevalence of common anaerobic bacteria in CF patients was investigated by Polymerase Chain Reaction (PCR). Results: The relationship between Bifidobacterium and Prevotella in both of healthy and CF groups, as well as the disease and Bifidobacterium (p = 0.0437) and disease and Prevotella (p = 0.0514), were significant. The results of Spearman's correlation also showed an inverse relationship between age and gender (men) with disease and a direct relationship between antibiotic use and disease. Conclusions: The abundance of potentially beneficial species of Bifidobacterium and Prevotella was lower in CF than in healthy people. The role of anaerobic bacteria in the lungs of CF patients is different according to the bacterial genus and species. © Journal of Krishna Institute of Medical Sciences University.

Style	Citing Format
MLA	Hamayeli H, et al.. "Investigation of Some Anaerobic Bacteria in the Sputum of Cystic Fibrosis Patients and Healthy People in Tehran, Iran." Journal of Krishna Institute of Medical Sciences University, vol. 13, no. 3, 2024, pp. 46-59.
APA	Hamayeli H, Abdiali A, Attaran B, Shafiei M, Modaresi M (2024). Investigation of Some Anaerobic Bacteria in the Sputum of Cystic Fibrosis Patients and Healthy People in Tehran, Iran. Journal of Krishna Institute of Medical Sciences University, 13(3), 46-59.
Chicago	Hamayeli H, Abdiali A, Attaran B, Shafiei M, Modaresi M. "Investigation of Some Anaerobic Bacteria in the Sputum of Cystic Fibrosis Patients and Healthy People in Tehran, Iran." Journal of Krishna Institute of Medical Sciences University 13, no. 3 (2024): 46-59.
Harvard	Hamayeli H et al. (2024) 'Investigation of Some Anaerobic Bacteria in the Sputum of Cystic Fibrosis Patients and Healthy People in Tehran, Iran', Journal of Krishna Institute of Medical Sciences University, 13(3), pp. 46-59.
Vancouver	Hamayeli H, Abdiali A, Attaran B, Shafiei M, Modaresi M. Investigation of Some Anaerobic Bacteria in the Sputum of Cystic Fibrosis Patients and Healthy People in Tehran, Iran. Journal of Krishna Institute of Medical Sciences University. 2024;13(3):46-59.
BibTex	@article{ author = {Hamayeli H and Abdiali A and Attaran B and Shafiei M and Modaresi M}, title = {Investigation of Some Anaerobic Bacteria in the Sputum of Cystic Fibrosis Patients and Healthy People in Tehran, Iran}, journal = {Journal of Krishna Institute of Medical Sciences University}, volume = {13}, number = {3}, pages = {46-59}, year = {2024} }
RIS	TY - JOUR AU - Hamayeli H AU - Abdiali A AU - Attaran B AU - Shafiei M AU - Modaresi M TI - Investigation of Some Anaerobic Bacteria in the Sputum of Cystic Fibrosis Patients and Healthy People in Tehran, Iran JO - Journal of Krishna Institute of Medical Sciences University VL - 13 IS - 3 SP - 46 EP - 59 PY - 2024 ER -

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