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Characterization and Antibacterial Activity of Phthalides From the Roots of the Mmedicinal Herb Levisticum Officinale W.D.J. Koch Publisher



Miran M1 ; Esfahani HM2 ; Jung JH3 ; Aliahmadi A4 ; Skropeta D5 ; Abbasmohammadi M6 ; Ebrahimi SN6 ; Farimani MM6
Authors
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Authors Affiliations
  1. 1. Department of Pharmacognosy and Biotechnology, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran
  2. 2. Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. College of Pharmacy, Pusan National University, Busan, South Korea
  4. 4. Department of Biology, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G.C., Evin, Tehran, Iran
  5. 5. Molecular Horizons and School of Chemistry & Molecular Bioscience, University of Wollongong, Wollongong, 2500, NSW, Australia
  6. 6. Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G.C., Evin, Tehran, Iran

Source: Iranian Journal of Pharmaceutical Research Published:2020


Abstract

A new phthalide, namely 7-methoxy-3-propylidenephthalide (1), along with two known compounds (2, 3) were isolated from the roots of the edible herb Levisticum officinale W.D.J. Koch, commonly known as lovage and well known in traditional medicine for its spasmolytic and diuretic effects. The structure of the new compound was established by HRMS and 1D & 2D NMR (1H1H COSY, HMQC, and HMBC) spectroscopic analysis. All compounds are reported for the first time from L. officinale. Compounds 1-3 were tested against two Gram negative (Escherichia coli, Pseudomonas aeruginosa) and two Gram positive (Staphylococcus aureus and vancomycin-resistant Enterococcus [VRE] faecium) bacteria strains. Compound 3 was active against S. aureus, E. coli and vancomycin-resistant E. faecium with MIC values of 16, 64, and 128 μg/mL, respectively. © 2020, Iranian Journal of Pharmaceutical Research. All rights reserved.
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