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Leishmania Tropica in Stray Dogs in Southeast Iran



Bamorovat M1 ; Sharifi I1 ; Dabiri S2 ; Mohammadi MA1 ; Fasihi Harandi M3 ; Mohebali M4 ; Aflatoonian MR5 ; Keyhani A1
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Authors Affiliations
  1. 1. Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran
  2. 2. Dept. of Pathology, Kerman University of Medical Sciences, Kerman, Iran
  3. 3. Research Center for Hydatid Disease, Kerman University of Medical Sciences, Kerman, Iran
  4. 4. Dept. of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran

Source: Iranian Journal of Public Health Published:2015

Abstract

Background: Cutaneous leishmaniasis (CL) caused by Leishmania tropica is endemic in Kerman, southeastern Iran. While dogs have long been implicated as the main domestic reservoirs of L. infantum, etiological agent of zoonotic visceral leishmaniasis (ZVL), they can also carry L. tropica infection. The objective of the present study was to deter-mine molecular identity and to evaluate histopathological changes due to CL in dogs in a well-known focus of anthro-ponotic CL (ACL) in Kerman, southeastern Iran. Methods: This study was carried out in three prospective series from 1994 to 2013 on dogs. Tissue samples were tak-en from 471 stray dogs. Pathological specimens including skin, spleen, liver and lymph nodes were prepared for paraf-fin blocks, sectioning and staining for further histopathological examination. PCR amplification of kDNA was per-formed to identify the causative agent and sequencing. Overall, two out of 471 stray dogs were infected with L. tropica. Hyperplasia of red pulp by the proliferation of histiocytes, lymphocytes, plasma cells and cytoplasm of histiocytes col-lection of amastigotes was noted. Results: Based on the results of PCR products and sequencing analysis, the parasites isolated from the lesions of two dogs were characterized as L. tropica, corresponding to a band of 830 bp Conclusion: This finding revealed infection with L. tropica in stray dogs in the city and suburbs of Kerman. This in-formation is essential for public health concerns and planning effective future control programs. The role of dogs as potentional reservoir in the epidemiology of ACL needs further investigation. © 2015, Iranian Journal of Public Health. All rights reserved.
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