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Correlation Between Serum Homocysteine Levels and Carotid Intima-Media Thickening in Hemodialysis Patients Publisher Pubmed



Soleimani A1 ; Tabatabaei SH1 ; Soleimani M2 ; Sinaeinejad M3 ; Ghazvini F4 ; Tabatabaei SZ5 ; Mofidi H6 ; Kashani M7 ; Mahmoudi STS8
Authors
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Authors Affiliations
  1. 1. Internal Medicine Department, Kashan University of Medical Sciences, Kashan, Iran
  2. 2. Ankara University faculty of pharmacy, Ankara, Turkey
  3. 3. Internal Medicine Department, Qom University of Medical Sciences, Qom, Iran
  4. 4. Yazd University of Medical Sciences, Yazd, Iran
  5. 5. Internal Medicine Department, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Faculty of Industrial Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
  7. 7. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Iranian Journal of Kidney Diseases Published:2023


Abstract

Introduction. Hyperhomocysteinemia is an important risk factor for cardiovascular disease in ESKD patients. Homocysteine, as an inflammatory factor, and carotid intima-media thickness (CIMT) could predict atherosclerosis in hemodialysis-treated ESKD patients. In this regard, the present study was conducted to investigate serum homocysteine level and its relationship with internal carotid intima thickness in ESKD patients undergoing routine hemodialysis. Methods. This study comprised 56 ESKD patients, older than 40 years, undergoing hemodialysis for at least 1 year. All participants were taking Nephrovit for at least 6 months. The study participants were patients who underwent ultrasonography for CIMT determination and laboratory test Results. There was no statistically significant relationship between the mean homocysteine level and hypertension, diabetes mellitus, duration of dialysis, and body mass index (BMI). Among the study participants, the results also showed that the mean value of CMIT homocysteine and C-reactive protein (CRP) were 0.89 millimeters, 30.44 (mcmol/L), and 35.60 mg/L; respectively. Despite hypertension, there was a significant difference between the mean values of CMIT in patients with diabetes mellitus and those who had been on dialysis for a longer period (more than 3 years). Also, the mean value of CMIT was significantly higher in obese patients than those with normal BMI. None of the other variables including homocysteine serum level, C-reactive protein (CRP), and CMIT showed a significant correlation. Conclusion. The results of the study suggest that there is no relationship between serum homocysteine level and carotid intima-media thickness in hemodialysis patients. © 2023, Iranian Society of Nephrology. All rights reserved.
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