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Review of Barrett's Oesophagus to Oesophageal Adenocarcinoma: New Prospect



Mozaffarinamin B1, 2 ; Daryani NE3 ; Dallal MMS4, 5
Authors
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Authors Affiliations
  1. 1. Department of Microbiology of Pathobiology, School of Public Health, Tehran University of Medical Sciences, International Campus (TUMS-IC), Tehran, Iran
  2. 2. Microbiology and Gut Biology Group, University of Dundee, Ninewells Hospital, Medical School, Dundee, United Kingdom
  3. 3. Department of Gastroenterology and Hepatology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Food Microbiology Research Center, Tehran University of Medical Sciences, International Campus (TUMS-IC), Tehran, Iran
  5. 5. Division of Food Microbiology, Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Govaresh Published:2015

Abstract

Today's knowledge on oesophageal adenocarcinoma and its rising incidence has encouraged researcher to illustrate relationship between Barrett's disease and progression to adenocarcinoma. The incidence of this disease has been accelerated sharply in current decades since people life has changed. Studies have been demonstrated that several potential factors including genetical and environmental factors are involved on Barrett's transformation. Using different detectable biomarkers and techniques have supported early recognition of adenocarcinoma but still have not clarified pathogenesis of Barrett's oesophagus to oesophageal adenocarcinoma. This review summarizes as much as information in relationship with those evidences that have been finalised in different aspects of cellular and molecular pathogenesis of OA. However, current data shows that bacteria might play new role in the pathogenesis of adenocarcinoma.
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