A Synthesis of Pyrazino[1,2-A]Indoles Via One-Pot Cascade Ugi Condensation and N-Annulation Under Mild Conditions

A Synthesis of Pyrazino[1,2-A]Indoles Via One-Pot Cascade Ugi Condensation and N-Annulation Under Mild Conditions Publisher

Peirow R¹ ; Adib M¹ ; Mahdavi M²

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1. School of Chemistry, College of Science, University of Tehran, PO Box 14155-6455, Tehran, Iran
2. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Tetrahedron Letters Published:2021

Abstract

A novel, one-pot, mild and operationally simple synthetic approach for the synthesis of pyrazino[1,2-a]indole derivatives is reported. The reaction proceeds via a 4-component Ugi condensation followed by N-annulation of the intermediate to afford the titled product under metal and acid-free conditions in methanol. The procedure consists of one-step tandem condensation and cyclization of Indole-2-carboxylic acid with isocyanides, phenacylamine hydrochloride and a variety of aromatic aldehydes. This method provides simple access to a wide range of pyrazino[1,2-a]indole derivatives in good to excellent yields under ambient temperature. © 2021

Style	Citing Format
MLA	Peirow R, Adib M, Mahdavi M. "A Synthesis of Pyrazino[1,2-A]Indoles Via One-Pot Cascade Ugi Condensation and N-Annulation Under Mild Conditions." Tetrahedron Letters, vol. 87, no. , 2021, pp. -.
APA	Peirow R, Adib M, Mahdavi M (2021). A Synthesis of Pyrazino[1,2-A]Indoles Via One-Pot Cascade Ugi Condensation and N-Annulation Under Mild Conditions. Tetrahedron Letters, 87(), -.
Chicago	Peirow R, Adib M, Mahdavi M. "A Synthesis of Pyrazino[1,2-A]Indoles Via One-Pot Cascade Ugi Condensation and N-Annulation Under Mild Conditions." Tetrahedron Letters 87, no. (2021): -.
Harvard	Peirow R, Adib M, Mahdavi M (2021) 'A Synthesis of Pyrazino[1,2-A]Indoles Via One-Pot Cascade Ugi Condensation and N-Annulation Under Mild Conditions', Tetrahedron Letters, 87(), pp. -.
Vancouver	Peirow R, Adib M, Mahdavi M. A Synthesis of Pyrazino[1,2-A]Indoles Via One-Pot Cascade Ugi Condensation and N-Annulation Under Mild Conditions. Tetrahedron Letters. 2021;87():-.
BibTex	@article{ author = {Peirow R and Adib M and Mahdavi M}, title = {A Synthesis of Pyrazino[1,2-A]Indoles Via One-Pot Cascade Ugi Condensation and N-Annulation Under Mild Conditions}, journal = {Tetrahedron Letters}, volume = {87}, number = {}, pages = {-}, year = {2021} }
RIS	TY - JOUR AU - Peirow R AU - Adib M AU - Mahdavi M TI - A Synthesis of Pyrazino[1,2-A]Indoles Via One-Pot Cascade Ugi Condensation and N-Annulation Under Mild Conditions JO - Tetrahedron Letters VL - 87 IS - SP - EP - PY - 2021 ER -

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