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A Study on Oxidative Stress, Hematological and Biochemical Parameters in Copper Smelter Workers Publisher



Alishahi M1, 2 ; Malekirad AA3, 4 ; Mandegary A2 ; Abdollahi M5, 6 ; Mozaffari A7 ; Ansari M8
Authors
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Authors Affiliations
  1. 1. Occupational Environment Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
  2. 2. Department of Pharmacology and Toxicology, School of Pharmacy and Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
  3. 3. Department of Biology, Payame Noor University, Tehran, Iran
  4. 4. Pharmaceutical Sciences Research Center, Tehran University of Medical Science, Tehran, Iran
  5. 5. Toxicology and Diseases Group, Pharmaceutical Sciences Research Center, Tehran University of Medical Science, Tehran, Iran
  6. 6. Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Occupational Health, School of Public Health, Kerman University of Medical Sciences, Kerman, Iran
  8. 8. Drug and Food Control Department, Faculty of Pharmacy, Kerman Medical Science University, Kerman, Iran

Source: Toxin Reviews Published:2017


Abstract

In a cross-sectional study, 44 shift workers at a copper smelter unit who had worked there at least for the last 4 years were selected as subjects and were matched with 44 people as controls. In workers, the mean glutathione peroxidase, catalase and total thiol levels were less than the control group. The average of biochemical parameters was significantly higher in workers. Exposure to high levels of copper and iron, lead, arsenic, and cadmium which are released during the process of copper smelting reduces the amounts of antioxident capacity, which leads to oxidative stress in smelter workers. © 2017 Informa UK Ltd, trading as Taylor & Francis Group.