A Randomized Controlled Trial of Effectiveness of Platelet-Rich Plasma Gel and Regular Dressing on Wound Healing Time in Pilonidal Sinus Surgery: Role of Different Affecting Factors

A Randomized Controlled Trial of Effectiveness of Platelet-Rich Plasma Gel and Regular Dressing on Wound Healing Time in Pilonidal Sinus Surgery: Role of Different Affecting Factors Publisher Pubmed

Mohamadi S¹ ; Norooznezhad AH^{2, 3} ; Mostafaei S^{3, 4} ; Nikbakht M¹ ; Nassiri S⁵ ; Safar H⁶ ; Moghaddam KA¹ ; Ghavamzadeh A¹ ; Kazemnejad A⁷

Source: Biomedical Journal Published:2019

Abstract

Background: The aim of this study was to assess the possible association between different factors such as age, sex, antibiotic consumption duration, angiogenesis and pain and “acceleration of wound healing” in pilonidal sinus patients after treating with platelet-rich plasma (PRP). Methods: In this clinical trial, 110 patients were randomly divided into treatment arm and control group. After surgery, control group underwent classic wound dressing and the treatment arm experienced PRP gel therapy. Before achieving complete healing, wound incisional biopsy was performed in order to evaluate angiogenesis. During the study, other data such as pain and antibiotic consumption duration were also collected. Wound healing time of pilonidal sinus disease was analyzed using Extended and Stratify Cox model. Data were analyzed using R and STATA software. p<0.05 were considered statistically significant. Results: The average wound volume was calculated 41.9 ± 8.01 cc in the controls and 42.35 ± 10.81 in the treatment arm group. The mean of healing time was 8.7 ± 1.18, 4.8 ± 0.87 weeks for control and treatment arm, respectively. There was a significant and strong negative association between healing time and wound volume (p<0.01). Moreover, a significant negative association was found between pain duration and angiogenesis (p<0.001), a strong positive significant association was found between healing time of the treatment arms (p<0.01), and the rate of wound healing for participants treated with PRP gel was 37.2 times more than that of controls. Conclusion: Authors hope for these finding to help the future researches to more thoroughly focus on the mentioned factors in order to find a suitable strategy for wound healing using PRP. © 2019 Chang Gung University

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Saeed Mohammadi (4)

Behnam Molavi (2)

Style	Citing Format
MLA	Mohamadi S, et al.. "A Randomized Controlled Trial of Effectiveness of Platelet-Rich Plasma Gel and Regular Dressing on Wound Healing Time in Pilonidal Sinus Surgery: Role of Different Affecting Factors." Biomedical Journal, vol. 42, no. 6, 2019, pp. 403-410.
APA	Mohamadi S, Norooznezhad AH, Mostafaei S, Nikbakht M, Nassiri S, Safar H, Moghaddam KA, Ghavamzadeh A, Kazemnejad A (2019). A Randomized Controlled Trial of Effectiveness of Platelet-Rich Plasma Gel and Regular Dressing on Wound Healing Time in Pilonidal Sinus Surgery: Role of Different Affecting Factors. Biomedical Journal, 42(6), 403-410.
Chicago	Mohamadi S, Norooznezhad AH, Mostafaei S, Nikbakht M, Nassiri S, Safar H, Moghaddam KA, Ghavamzadeh A, Kazemnejad A. "A Randomized Controlled Trial of Effectiveness of Platelet-Rich Plasma Gel and Regular Dressing on Wound Healing Time in Pilonidal Sinus Surgery: Role of Different Affecting Factors." Biomedical Journal 42, no. 6 (2019): 403-410.
Harvard	Mohamadi S et al. (2019) 'A Randomized Controlled Trial of Effectiveness of Platelet-Rich Plasma Gel and Regular Dressing on Wound Healing Time in Pilonidal Sinus Surgery: Role of Different Affecting Factors', Biomedical Journal, 42(6), pp. 403-410.
Vancouver	Mohamadi S, Norooznezhad AH, Mostafaei S, Nikbakht M, Nassiri S, Safar H, et al.. A Randomized Controlled Trial of Effectiveness of Platelet-Rich Plasma Gel and Regular Dressing on Wound Healing Time in Pilonidal Sinus Surgery: Role of Different Affecting Factors. Biomedical Journal. 2019;42(6):403-410.
BibTex	@article{ author = {Mohamadi S and Norooznezhad AH and Mostafaei S and Nikbakht M and Nassiri S and Safar H and Moghaddam KA and Ghavamzadeh A and Kazemnejad A}, title = {A Randomized Controlled Trial of Effectiveness of Platelet-Rich Plasma Gel and Regular Dressing on Wound Healing Time in Pilonidal Sinus Surgery: Role of Different Affecting Factors}, journal = {Biomedical Journal}, volume = {42}, number = {6}, pages = {403-410}, year = {2019} }
RIS	TY - JOUR AU - Mohamadi S AU - Norooznezhad AH AU - Mostafaei S AU - Nikbakht M AU - Nassiri S AU - Safar H AU - Moghaddam KA AU - Ghavamzadeh A AU - Kazemnejad A TI - A Randomized Controlled Trial of Effectiveness of Platelet-Rich Plasma Gel and Regular Dressing on Wound Healing Time in Pilonidal Sinus Surgery: Role of Different Affecting Factors JO - Biomedical Journal VL - 42 IS - 6 SP - 403 EP - 410 PY - 2019 ER -

Style

Citing Format

MLA

Mohamadi S, et al.. "A Randomized Controlled Trial of Effectiveness of Platelet-Rich Plasma Gel and Regular Dressing on Wound Healing Time in Pilonidal Sinus Surgery: Role of Different Affecting Factors." Biomedical Journal, vol. 42, no. 6, 2019, pp. 403-410.

APA

Mohamadi S, Norooznezhad AH, Mostafaei S, Nikbakht M, Nassiri S, Safar H, Moghaddam KA, Ghavamzadeh A, Kazemnejad A (2019). A Randomized Controlled Trial of Effectiveness of Platelet-Rich Plasma Gel and Regular Dressing on Wound Healing Time in Pilonidal Sinus Surgery: Role of Different Affecting Factors. Biomedical Journal, 42(6), 403-410.

Chicago

Mohamadi S, Norooznezhad AH, Mostafaei S, Nikbakht M, Nassiri S, Safar H, Moghaddam KA, Ghavamzadeh A, Kazemnejad A. "A Randomized Controlled Trial of Effectiveness of Platelet-Rich Plasma Gel and Regular Dressing on Wound Healing Time in Pilonidal Sinus Surgery: Role of Different Affecting Factors." Biomedical Journal 42, no. 6 (2019): 403-410.

Harvard

Mohamadi S et al. (2019) 'A Randomized Controlled Trial of Effectiveness of Platelet-Rich Plasma Gel and Regular Dressing on Wound Healing Time in Pilonidal Sinus Surgery: Role of Different Affecting Factors', Biomedical Journal, 42(6), pp. 403-410.

Vancouver

Mohamadi S, Norooznezhad AH, Mostafaei S, Nikbakht M, Nassiri S, Safar H, et al.. A Randomized Controlled Trial of Effectiveness of Platelet-Rich Plasma Gel and Regular Dressing on Wound Healing Time in Pilonidal Sinus Surgery: Role of Different Affecting Factors. Biomedical Journal. 2019;42(6):403-410.

BibTex

@article{ author = {Mohamadi S and Norooznezhad AH and Mostafaei S and Nikbakht M and Nassiri S and Safar H and Moghaddam KA and Ghavamzadeh A and Kazemnejad A}, title = {A Randomized Controlled Trial of Effectiveness of Platelet-Rich Plasma Gel and Regular Dressing on Wound Healing Time in Pilonidal Sinus Surgery: Role of Different Affecting Factors}, journal = {Biomedical Journal}, volume = {42}, number = {6}, pages = {403-410}, year = {2019} }

RIS

TY - JOUR
AU - Mohamadi S
AU - Norooznezhad AH
AU - Mostafaei S
AU - Nikbakht M
AU - Nassiri S
AU - Safar H
AU - Moghaddam KA
AU - Ghavamzadeh A
AU - Kazemnejad A
TI - A Randomized Controlled Trial of Effectiveness of Platelet-Rich Plasma Gel and Regular Dressing on Wound Healing Time in Pilonidal Sinus Surgery: Role of Different Affecting Factors
JO - Biomedical Journal
VL - 42
IS - 6
SP - 403
EP - 410
PY - 2019
ER -

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Abstract