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A Randomized Controlled Trial of Effectiveness of Platelet-Rich Plasma Gel and Regular Dressing on Wound Healing Time in Pilonidal Sinus Surgery: Role of Different Affecting Factors Publisher Pubmed



Mohamadi S1 ; Norooznezhad AH2, 3 ; Mostafaei S3, 4 ; Nikbakht M1 ; Nassiri S5 ; Safar H6 ; Moghaddam KA1 ; Ghavamzadeh A1 ; Kazemnejad A7
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Authors Affiliations
  1. 1. Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Regenerative Medicine Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  3. 3. Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
  4. 4. Epidemiology and Biostatistics Unit, Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Surgery Ward, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Pathology Ward, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Source: Biomedical Journal Published:2019


Abstract

Background: The aim of this study was to assess the possible association between different factors such as age, sex, antibiotic consumption duration, angiogenesis and pain and “acceleration of wound healing” in pilonidal sinus patients after treating with platelet-rich plasma (PRP). Methods: In this clinical trial, 110 patients were randomly divided into treatment arm and control group. After surgery, control group underwent classic wound dressing and the treatment arm experienced PRP gel therapy. Before achieving complete healing, wound incisional biopsy was performed in order to evaluate angiogenesis. During the study, other data such as pain and antibiotic consumption duration were also collected. Wound healing time of pilonidal sinus disease was analyzed using Extended and Stratify Cox model. Data were analyzed using R and STATA software. p<0.05 were considered statistically significant. Results: The average wound volume was calculated 41.9 ± 8.01 cc in the controls and 42.35 ± 10.81 in the treatment arm group. The mean of healing time was 8.7 ± 1.18, 4.8 ± 0.87 weeks for control and treatment arm, respectively. There was a significant and strong negative association between healing time and wound volume (p<0.01). Moreover, a significant negative association was found between pain duration and angiogenesis (p<0.001), a strong positive significant association was found between healing time of the treatment arms (p<0.01), and the rate of wound healing for participants treated with PRP gel was 37.2 times more than that of controls. Conclusion: Authors hope for these finding to help the future researches to more thoroughly focus on the mentioned factors in order to find a suitable strategy for wound healing using PRP. © 2019 Chang Gung University
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