Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Inhaled Toxins: A Threat to Male Reproductive Health Publisher Pubmed



Mohammadzadeh M1, 2 ; Khoshakhlagh AH3 ; Calderongarciduenas L4 ; Cardona Maya WD5 ; Cai T6, 7
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Health in Emergencies and Disasters, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Climate Change and Health Research Center (CCHRC), Institute for Environmental Research (IER), Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Occupational Health Engineering, School of Health, Kashan University of Medical Sciences, Kashan, Iran
  4. 4. College of Health, The University of Montana, Missoula, 59812, MT, United States
  5. 5. Reproduction Group, Faculty of Medicine, University of Antioquia, Colombia
  6. 6. Department of Urology, Santa Chiara Regional Hospital, Trento, Italy
  7. 7. Institute of Clinical Medicine, University of Oslo, Oslo, Norway

Source: Ecotoxicology and Environmental Safety Published:2024


Abstract

Exposure to air pollutants is known to be an important risk factor in reducing semen quality in men across the world. Poor semen quality results in decline in the global fertility rate and significant personal stress, dysfunctional sexual relationships, and psychosocial problems. Continuous monitoring and effective efforts to reduce air pollution in industries and the environment and making positive changes in daily lifestyle can prevent adverse effects on semen quality and reduce the high prevalence of men infertility. This review aims to summarize studies associating pollutant concentrations of polycyclic aromatic hydrocarbons (PAHs), formaldehyde (FA), and BTEX (benzene, toluene, ethyl-benzene, and xylene) on semen quality. In this systematic review, Scopus, PubMed and Web of Science databases were searched until November 13, 2022. The PECO statement was formulated to clarify the research question, and articles that did not satisfy the criteria outlined in this statement were excluded. Generally, 497 articles were obtained through searching databases, and after the investigations, 26 articles that met the entry criteria were extracted and finally considered in the systematic review. The results showed that occupational and environmental exposures to PAHs, formaldehyde, and BTEX were associated with increased metabolite concentration of toxic pollutants in body fluids. These toxin-associated pollutants directly or indirectly cause detrimental effects on sperm motility, vitality, DNA fragmentation, and morphology. There is evidence on the impact of PAHs, formaldehyde, and BTEX pollutants on the reduction of semen quality. Therefore, proving the relationship between air pollutants and testicular function in semen quality can play an effective role in macro policies and adopting stricter laws to reduce the emission of air pollutants and promote a healthy lifestyle to improve reproductive health in young men. © 2024 The Authors
Related Docs
1. Sperm Epigenetics and Male Infertility: Unraveling the Molecular Puzzle, Human Genomics (2024)
2. Downward Trend in Male Reproductive Health and Fertility in Eastern Iran, Urologia Journal (2024)
3. Environmental and Lifestyle Factors Affecting Exposure to Polycyclic Aromatic Hydrocarbons in the General Population in a Middle Eastern Area, Environmental Pollution (2018)
Experts (# of related papers)
View all Related Experts
Sasan Faridi (1)
Kamyar Yaghmaeian (1)