Synthesis of Cytotoxic Isodeoxypodophyllotoxin Analogs

Synthesis of Cytotoxic Isodeoxypodophyllotoxin Analogs Publisher

Alizadeh BH¹ ; Emami S³ ; Dehghan G⁴ ; Foroumadi A⁵ ; Shafiee A⁵

Show Affiliations

1. Iranian Research Institute of Plant Protection (IRIPP), Shahid Chamran Avenue, Yaman St. No 1
2. P.O. Box: 1454, Tehran, Iran
3. Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
4. Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
5. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Heterocyclic Chemistry Published:2017

Abstract

A series of aryltetralin lignans 7a, 7b, 7c, 7d, 7e, 7f, 7g, 7h, 7i, 7j, 7k, 7l were synthesized as cytotoxic isodeoxypodophyllotoxin analogs. The title compounds 7a, 7b, 7c, 7d, 7e, 7f, 7g, 7h, 7i, 7j, 7k, 7l were synthesized from the reaction of (+)-(R)-4-[benzo(d)(1,3)dioxol-5-ylmethyl]-dihydrofuran-2-(3H)-one with different arylaldehydes to afford benzyl alcohol analogs and subsequent cyclization with trifluoroacetic acid in dichromethane. The preliminary screening of the compounds against viability of blood cancer human cell line K562 revealed that compounds 7d, 7e, and 7f had higher inhibitory activity at 10 µg/mL concentration compared with etoposide as reference drug. © 2016 Wiley Periodicals, Inc.

Style	Citing Format
MLA	Alizadeh BH, et al.. "Synthesis of Cytotoxic Isodeoxypodophyllotoxin Analogs." Journal of Heterocyclic Chemistry, vol. 54, no. 1, 2017, pp. 539-545.
APA	Alizadeh BH, Emami S, Dehghan G, Foroumadi A, Shafiee A (2017). Synthesis of Cytotoxic Isodeoxypodophyllotoxin Analogs. Journal of Heterocyclic Chemistry, 54(1), 539-545.
Chicago	Alizadeh BH, Emami S, Dehghan G, Foroumadi A, Shafiee A. "Synthesis of Cytotoxic Isodeoxypodophyllotoxin Analogs." Journal of Heterocyclic Chemistry 54, no. 1 (2017): 539-545.
Harvard	Alizadeh BH et al. (2017) 'Synthesis of Cytotoxic Isodeoxypodophyllotoxin Analogs', Journal of Heterocyclic Chemistry, 54(1), pp. 539-545.
Vancouver	Alizadeh BH, Emami S, Dehghan G, Foroumadi A, Shafiee A. Synthesis of Cytotoxic Isodeoxypodophyllotoxin Analogs. Journal of Heterocyclic Chemistry. 2017;54(1):539-545.
BibTex	@article{ author = {Alizadeh BH and Emami S and Dehghan G and Foroumadi A and Shafiee A}, title = {Synthesis of Cytotoxic Isodeoxypodophyllotoxin Analogs}, journal = {Journal of Heterocyclic Chemistry}, volume = {54}, number = {1}, pages = {539-545}, year = {2017} }
RIS	TY - JOUR AU - Alizadeh BH AU - Emami S AU - Dehghan G AU - Foroumadi A AU - Shafiee A TI - Synthesis of Cytotoxic Isodeoxypodophyllotoxin Analogs JO - Journal of Heterocyclic Chemistry VL - 54 IS - 1 SP - 539 EP - 545 PY - 2017 ER -

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