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Lipoic Acid Function and Its Safety in Multiple Sclerosis Publisher



Azimi A1 ; Khalili M2
Authors
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Authors Affiliations
  1. 1. MS Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Neuroscience Research Center, Tabriz University of Medical Science, Tabriz, Iran

Source: Probiotics# Prebiotics# and Synbiotics: Bioactive Foods in Health Promotion Published:2016


Abstract

Lipoic acid (LA), is an essential cofactor for mitochondria enzymes, with some biological functions, such as antioxidant and anti-inflammatory effects has been interested in diabetic neuropathy and neurodegenerative diseases. Multiple sclerosis (MS) is a chronic demyelinative inflammatory process of the central nervous system. Besides immunosuppressant drugs, nutritional supplement such as LA has been studied in MS. Pharmacokinetics (PK) evaluation found that LA had rapid absorption and clearance in human and animal models of MS. Furthermore, LA as an oral supplement was tolerated up to 1200. mg/days in MS patients and no severe side effects were reported. Generally, beneficial effects of LA in MS were observed in aspects of molecular mediators, antioxidant, and inflammatory markers. In conclusion, further trials with longer duration with clinical and imaging assessment are suggested. © 2016 Elsevier Inc.
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