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Analytical Techniques for the Determination of Verapamil in Biological Samples and Dosage Forms: An Overview Publisher Pubmed



Pourkarim F1 ; Rahimpour E2 ; Jouyban A3, 4
Authors
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Authors Affiliations
  1. 1. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, 5165665811, Iran
  2. 2. Food and Drug Safety Research Center, Tabriz University of Medical Sciences, Tabriz, 5165665811, Iran
  3. 3. Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, 5165665811, Iran
  4. 4. Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, 1411713135, Iran

Source: Bioanalysis Published:2019


Abstract

Verapamil (VER) is a calcium channel blocker that is widely used to treat various cardiovascular diseases and is also effective in migraine prophylaxis. As the therapeutic range of VER is very narrow and toxicity can occur in patients after oral administration, therapeutic drug monitoring is recommended to optimize pharmacotherapy. The choice of an appropriate bioanalytical method for therapeutic drug monitoring of VER in the biological samples is a very important step in achieving fast and reliable results. This review focuses on the various analytical methods reported between 1976 and 2019 for the determination of VER in different biological samples and pharmaceutical dosage forms along with their methodological limitations. This review provides an overview for pharmaceutical industry researchers, clinicians and clinical chemists. © 2019 Newlands Press.
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