The Effect of Viola Odorata Flower Syrup on the Cough of Children With Asthma: A Double-Blind, Randomized Controlled Trial Publisher Pubmed



Qasemzadeh MJ¹ ; Sharifi H² ; Hamedanian M¹ ; Gharehbeglou M¹ ; Heydari M³ ; Sardari M² ; Akhlaghdoust M⁴ ; Minae MB² Show Affiliations
Source: Journal of Evidence-Based Complementary and Alternative Medicine Published:2015

Abstract

This study aimed to investigate the effect of violet syrup on cough alleviation in children with intermittent asthma. In a parallel, double-blind, randomized controlled trial, 182 children aged 2 to 12 years with intermittent asthma were randomly assigned 1:1 to receive violet syrup or placebo along with the common standard treatments in both groups (short-acting β-agonist). Both groups were evaluated in terms of the duration until cough suppression was achieved. No significant difference was observed in basic characteristics. The duration lasting to yield more than 50% cough reduction and 100% cough suppression was significantly less in the violet syrup group compared to placebo (P =.001, P <.001, respectively). There was no significant difference in therapeutic effects between boys and girls. There was a significant inverse correlation between the age of children and rate of cough alleviation and suppression by violet syrup. This study showed that the adjuvant use of violet syrup with short-acting β-agonist can enhance the cough suppression in children with intermittent asthma. © 2015, The Author(s) 2015.