Risk Factors for a Severe Disease Course in Children With Sars-Cov-2 Infection Following Hematopoietic Cell Transplantation in the Pre-Omicron Period: A Prospective Multinational Infectious Disease Working Party From the European Society for Blood and Marrow Transplantation Group (Ebmt) and the Spanish Group of Hematopoietic Stem Cell Transplantation (Geth) Study

Risk Factors for a Severe Disease Course in Children With Sars-Cov-2 Infection Following Hematopoietic Cell Transplantation in the Pre-Omicron Period: A Prospective Multinational Infectious Disease Working Party From the European Society for Blood and Marrow Transplantation Group (Ebmt) and the Spanish Group of Hematopoietic Stem Cell Transplantation (Geth) Study Publisher Pubmed

Averbuch D¹ ; De La Camara R² ; Tridello G³ ; Knelange NS⁴ ; Bykova TA⁵ ; Ifversen M⁶ ; Dobsinska V^{7, 8} ; Ayas M⁹ ; Hamidieh AA¹⁰ ; Pichler H¹¹ ; Perezmartinez A¹² ; Cesaro S³ ; Sundin M¹³ ; Badell I¹⁴ Show All Authors

Averbuch D¹
De La Camara R²
Tridello G³
Knelange NS⁴
Bykova TA⁵
Ifversen M⁶
Dobsinska V^{7, 8}
Ayas M⁹
Hamidieh AA¹⁰
Pichler H¹¹
Perezmartinez A¹²
Cesaro S³
Sundin M¹³
Badell I¹⁴
Bader P¹⁵
Johansson JE¹⁶
Mircidanicar O¹⁷
Sedlacek P¹⁸
Paillard C¹⁹
Gibson B²⁰
Lawson S²¹
Kroeger N²²
Corbacioglu S²³
Mikulska M²⁴
Pinana JL²⁵
Styczynski J²⁶
Ljungman P²⁷

Show Affiliations

1. Faculty of Medicine, Hebrew University of Jerusalem, Pediatric Infectious Diseases, Hadassah Medical Center, Jerusalem, Israel
2. Hematology Department, Hospital Universitario de La Princesa, Madrid, Spain
3. Pediatric Hematology Oncology, Department of Mother and Child, Azienda Ospedaliera Universitaria Integrata, Verona, Italy
4. EBMT - Leiden Study Unit, Leiden, Netherlands
5. RM Gorbacheva Research Institute, Pavlov University, St. Petersburg, Russian Federation
6. Department of Children and Adolescents Medicine, Stem Cell Transplant Unit, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
7. Department of Pediatric Hematology and Oncology, Comenius University, Bratislava, Slovakia
8. Bone Marrow Transplantation Unit, National Institute of Childrenâ€™s Diseases, Bratislava, Slovakia
9. Pediatric Hematology/Oncology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
10. Pediatric Cell and Gene Therapy Research Center, Gene, Cell & Tissue Research Institute, Tehran University of Medical Sciences, Tehran, Iran
11. Department of Pediatric Hematology and Oncology, St. Anna Childrenâ€™s Hospital, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria
12. Department of Pediatric Hematology and Oncology, Hospital Universitario La Paz, Madrid, Spain
13. Section of Pediatric Hematology, Immunology and HCT, Astrid Lindgren Childrenâ€™s Hospital, Karolinska University Hospital and Division of Pediatrics, CLINTEC, Karolinska Institutet, Stockholm, Sweden
14. Pediatric BMT Unit, Hospital Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
15. Universitaetsklinikum Frankfurt Goethe-Universitaet, Frankfurt Main, Germany
16. Sahlgrenska University Hospital, Goeteborg, Sweden
17. BMT Unit, Bristol Royal Hospital for Children, Bristol, United Kingdom
18. HSCT Unit, Department of Paediatric Haematology and Oncology, University Hospital Motol, Prague, Czech Republic
19. Pediatric Hematology Oncology, Hautepierre Hospital, Strasbourg University, Strasbourg, France
20. Department of Haematology, Royal Hospital for Children, Glasgow, United Kingdom
21. Department of Haematology, Birmingham Childrenâ€™s Hospital, Birmingham, United Kingdom
22. Department of Stem Cell Transplantation, University Hospital Eppendorf, Hamburg, Germany
23. Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, University of Regensburg, Regensburg, Germany
24. Division of Infectious Diseases, University of Genova, Ospedale Policlinco San Martino, Genova, Italy
25. Hospital Clinico Universitario de Valencia. Fundacion de investigacion INCLIVA, Hospital Clinico Universitario de Valencia, Valencia, Spain
26. Pediatric Hematology and Oncology, University Hospital, Collegium Medicum, Nicolaus Copernicus University Torun, Bydgoszcz, Poland
27. Department of Cellular Therapy and Allogeneic Stem Cell Transplantation, Karolinska Comprehensive Cancer Center, Karolinska University Hospital Huddinge, Division of Hematology, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden

Source: Bone Marrow Transplantation Published:2023

Abstract

Risk factors for severe SARS-Cov-2 infection course are poorly described in children following hematopoietic cell transplantation (HCT). In this international study, we analyzed factors associated with a severe course (intensive care unit (ICU) admission and/or mortality) in post-HCT children. Eighty-nine children (58% male; median age 9 years (min-max 1–18)) who received an allogeneic (85; 96%) or an autologous (4; 4%) HCT were reported from 28 centers (18 countries). Median time from HCT to SARS-Cov-2 infection was 7 months (min-max 0–181). The most common clinical manifestations included fever (37; 42%) and cough (26; 29%); 37 (42%) were asymptomatic. Nine (10%) children following allo-HCT required ICU care. Seven children (8%) following allo-HCT, died at a median of 22 days after SARS-Cov-2 diagnosis. In a univariate analysis, the probability of a severe disease course was higher in allo-HCT children with chronic GVHD, non-malignant disease, immune suppressive treatment (specifically, mycophenolate), moderate immunodeficiency score, low Lansky score, fever, cough, coinfection, pulmonary radiological findings, and high C-reactive protein. In conclusion, SARS-Cov-2 infection in children following HCT was frequently asymptomatic. Despite this, 10% needed ICU admission and 8% died in our cohort. Certain HCT, underlying disease, and SARS-Cov-2 related factors were associated with a severe disease course. © 2023, The Author(s), under exclusive licence to Springer Nature Limited.

Experts (# of related papers)

View all Related Experts

Mohammad Vaezi (1)

Maryam Barkhordar (1)

Style	Citing Format
MLA	Averbuch D, et al.. "Risk Factors for a Severe Disease Course in Children With Sars-Cov-2 Infection Following Hematopoietic Cell Transplantation in the Pre-Omicron Period: A Prospective Multinational Infectious Disease Working Party From the European Society for Blood and Marrow Transplantation Group (Ebmt) and the Spanish Group of Hematopoietic Stem Cell Transplantation (Geth) Study." Bone Marrow Transplantation, vol. 58, no. 5, 2023, pp. 558-566.
APA	Averbuch D, De La Camara R, Tridello G, Knelange NS, Bykova TA, Ifversen M, Dobsinska V, Ayas M, Hamidieh AA, Pichler H, Perezmartinez A, Cesaro S, Sundin M, Badell I, Bader P, Johansson JE, Mircidanicar O, Sedlacek P, Paillard C, ... Ljungman P (2023). Risk Factors for a Severe Disease Course in Children With Sars-Cov-2 Infection Following Hematopoietic Cell Transplantation in the Pre-Omicron Period: A Prospective Multinational Infectious Disease Working Party From the European Society for Blood and Marrow Transplantation Group (Ebmt) and the Spanish Group of Hematopoietic Stem Cell Transplantation (Geth) Study. Bone Marrow Transplantation, 58(5), 558-566.
Chicago	Averbuch D, De La Camara R, Tridello G, Knelange NS, Bykova TA, Ifversen M, Dobsinska V, et al.. "Risk Factors for a Severe Disease Course in Children With Sars-Cov-2 Infection Following Hematopoietic Cell Transplantation in the Pre-Omicron Period: A Prospective Multinational Infectious Disease Working Party From the European Society for Blood and Marrow Transplantation Group (Ebmt) and the Spanish Group of Hematopoietic Stem Cell Transplantation (Geth) Study." Bone Marrow Transplantation 58, no. 5 (2023): 558-566.
Harvard	Averbuch D et al. (2023) 'Risk Factors for a Severe Disease Course in Children With Sars-Cov-2 Infection Following Hematopoietic Cell Transplantation in the Pre-Omicron Period: A Prospective Multinational Infectious Disease Working Party From the European Society for Blood and Marrow Transplantation Group (Ebmt) and the Spanish Group of Hematopoietic Stem Cell Transplantation (Geth) Study', Bone Marrow Transplantation, 58(5), pp. 558-566.
Vancouver	Averbuch D, De La Camara R, Tridello G, Knelange NS, Bykova TA, Ifversen M, et al.. Risk Factors for a Severe Disease Course in Children With Sars-Cov-2 Infection Following Hematopoietic Cell Transplantation in the Pre-Omicron Period: A Prospective Multinational Infectious Disease Working Party From the European Society for Blood and Marrow Transplantation Group (Ebmt) and the Spanish Group of Hematopoietic Stem Cell Transplantation (Geth) Study. Bone Marrow Transplantation. 2023;58(5):558-566.
BibTex	@article{ author = {Averbuch D and De La Camara R and Tridello G and Knelange NS and Bykova TA and Ifversen M and Dobsinska V and Ayas M and Hamidieh AA and Pichler H and Perezmartinez A and Cesaro S and Sundin M and Badell I and Bader P and Johansson JE and Mircidanicar O and Sedlacek P and Paillard C and Gibson B and Lawson S and Kroeger N and Corbacioglu S and Mikulska M and Pinana JL and Styczynski J and Ljungman P}, title = {Risk Factors for a Severe Disease Course in Children With Sars-Cov-2 Infection Following Hematopoietic Cell Transplantation in the Pre-Omicron Period: A Prospective Multinational Infectious Disease Working Party From the European Society for Blood and Marrow Transplantation Group (Ebmt) and the Spanish Group of Hematopoietic Stem Cell Transplantation (Geth) Study}, journal = {Bone Marrow Transplantation}, volume = {58}, number = {5}, pages = {558-566}, year = {2023} }
RIS	TY - JOUR AU - Averbuch D AU - De La Camara R AU - Tridello G AU - Knelange NS AU - Bykova TA AU - Ifversen M AU - Dobsinska V AU - Ayas M AU - Hamidieh AA AU - Pichler H AU - Perezmartinez A AU - Cesaro S AU - Sundin M AU - Badell I AU - Bader P AU - Johansson JE AU - Mircidanicar O AU - Sedlacek P AU - Paillard C AU - Gibson B AU - Lawson S AU - Kroeger N AU - Corbacioglu S AU - Mikulska M AU - Pinana JL AU - Styczynski J AU - Ljungman P TI - Risk Factors for a Severe Disease Course in Children With Sars-Cov-2 Infection Following Hematopoietic Cell Transplantation in the Pre-Omicron Period: A Prospective Multinational Infectious Disease Working Party From the European Society for Blood and Marrow Transplantation Group (Ebmt) and the Spanish Group of Hematopoietic Stem Cell Transplantation (Geth) Study JO - Bone Marrow Transplantation VL - 58 IS - 5 SP - 558 EP - 566 PY - 2023 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract