The Value of Urea, Creatinine, Prolactin, and Beta Sub-Unit of Human Chorionic Gonadotropin of Vaginal Fluid in the Diagnosis of Premature Preterm Rupture of Membranes in Pregnancy; [Gebelikte Premature Preterm Membran Rupturu Tanisinda Vajinal Sivida Ure, Kreatinin, Prolaktin Ve Beta-Insan Koryonik Gonadotropinin Degeri]

The Value of Urea, Creatinine, Prolactin, and Beta Sub-Unit of Human Chorionic Gonadotropin of Vaginal Fluid in the Diagnosis of Premature Preterm Rupture of Membranes in Pregnancy; [Gebelikte Premature Preterm Membran Rupturu Tanisinda Vajinal Sivida Ure, Kreatinin, Prolaktin Ve Beta-Insan Koryonik Gonadotropinin Degeri] Publisher

Ghasemi M^{1, 2} ; Jaami R² ; Alleyassin A³ ; Ansarimoghaddam A⁴

Show Affiliations

1. Zahedan University of Medical Sciences, Reproductive Health Research Center, Zahedan, Iran
2. Zahedan University of Medical Sciences, Ali-Ibn Abitaleb Hospital, Clinic of Obstetrics and Gynecology, Zahedan, Iran
3. Tehran University of Medical Sciences, Shariati Hospital, Clinic of Obstetrics and Gynecology, Tehran, Iran
4. Zahedan University of Medical Sciences, Department of Epidemiology and Health, Zahedan, Iran

Source: Turkish Journal of Obstetrics and Gynecology Published:2016

Abstract

Objective: To evaluate the effectiveness of urea, creatinine, prolactin, and the beta sub-unit of human chorionic gonadotropin (β-hCG) of vaginal fluid in the diagnosis premature preterm rupture of membranes (PROM). Materials and Methods: In this observational study, 160 pregnant women with gestational age of 28 to 40 weeks were divided into two equal groups: investigation (documented PROM) and control (intact membrane) groups. Five cubic centimeters of normal saline was poured into the vagina of all participants and the liquid was extracted after a few minutes using a syringe. The liquid was sent to a laboratory for examination. Data were analyzed using a t-test. Results: The volume of urea, creatinine, prolactin, and β-hCG was significantly different in the two groups (p<0.001). Based on receiver operating characteristic curve and cut-off point, sensitivity, specificity, positive and negative predictive values of β-hCG for detecting PROM were 87.5%, 86%, 86.4%, and 87.3%, respectively. Also, the same factors for urea in detecting PROM were 79.7%, 82.5%, 81.8%, and 80.4%, respectively. Creatinine had 74.6% sensitivity, 85% specificity, and 83% and 77.2% positive and negative predictive values for detecting PROM. Finally, prolactin had 87.5% sensitivity, 90% specificity, and 90% positive and 88% negative predictive values for detecting PROM. Conclusion: Prolactin and β-hCG have more diagnostic value than urea and creatinine in detecting PROM, and can be used in suspected cases. © 2016, Turkish Society of Obstetrics and Gynecology. All rights reserved.

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Experts (# of related papers)

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Style	Citing Format
MLA	Ghasemi M, et al.. "The Value of Urea, Creatinine, Prolactin, and Beta Sub-Unit of Human Chorionic Gonadotropin of Vaginal Fluid in the Diagnosis of Premature Preterm Rupture of Membranes in Pregnancy; [Gebelikte Premature Preterm Membran Rupturu Tanisinda Vajinal Sivida Ure, Kreatinin, Prolaktin Ve Beta-Insan Koryonik Gonadotropinin Degeri]." Turkish Journal of Obstetrics and Gynecology, vol. 13, no. 2, 2016, pp. 62-66.
APA	Ghasemi M, Jaami R, Alleyassin A, Ansarimoghaddam A (2016). The Value of Urea, Creatinine, Prolactin, and Beta Sub-Unit of Human Chorionic Gonadotropin of Vaginal Fluid in the Diagnosis of Premature Preterm Rupture of Membranes in Pregnancy; [Gebelikte Premature Preterm Membran Rupturu Tanisinda Vajinal Sivida Ure, Kreatinin, Prolaktin Ve Beta-Insan Koryonik Gonadotropinin Degeri]. Turkish Journal of Obstetrics and Gynecology, 13(2), 62-66.
Chicago	Ghasemi M, Jaami R, Alleyassin A, Ansarimoghaddam A. "The Value of Urea, Creatinine, Prolactin, and Beta Sub-Unit of Human Chorionic Gonadotropin of Vaginal Fluid in the Diagnosis of Premature Preterm Rupture of Membranes in Pregnancy; [Gebelikte Premature Preterm Membran Rupturu Tanisinda Vajinal Sivida Ure, Kreatinin, Prolaktin Ve Beta-Insan Koryonik Gonadotropinin Degeri]." Turkish Journal of Obstetrics and Gynecology 13, no. 2 (2016): 62-66.
Harvard	Ghasemi M et al. (2016) 'The Value of Urea, Creatinine, Prolactin, and Beta Sub-Unit of Human Chorionic Gonadotropin of Vaginal Fluid in the Diagnosis of Premature Preterm Rupture of Membranes in Pregnancy; [Gebelikte Premature Preterm Membran Rupturu Tanisinda Vajinal Sivida Ure, Kreatinin, Prolaktin Ve Beta-Insan Koryonik Gonadotropinin Degeri]', Turkish Journal of Obstetrics and Gynecology, 13(2), pp. 62-66.
Vancouver	Ghasemi M, Jaami R, Alleyassin A, Ansarimoghaddam A. The Value of Urea, Creatinine, Prolactin, and Beta Sub-Unit of Human Chorionic Gonadotropin of Vaginal Fluid in the Diagnosis of Premature Preterm Rupture of Membranes in Pregnancy; [Gebelikte Premature Preterm Membran Rupturu Tanisinda Vajinal Sivida Ure, Kreatinin, Prolaktin Ve Beta-Insan Koryonik Gonadotropinin Degeri]. Turkish Journal of Obstetrics and Gynecology. 2016;13(2):62-66.
BibTex	@article{ author = {Ghasemi M and Jaami R and Alleyassin A and Ansarimoghaddam A}, title = {The Value of Urea, Creatinine, Prolactin, and Beta Sub-Unit of Human Chorionic Gonadotropin of Vaginal Fluid in the Diagnosis of Premature Preterm Rupture of Membranes in Pregnancy; [Gebelikte Premature Preterm Membran Rupturu Tanisinda Vajinal Sivida Ure, Kreatinin, Prolaktin Ve Beta-Insan Koryonik Gonadotropinin Degeri]}, journal = {Turkish Journal of Obstetrics and Gynecology}, volume = {13}, number = {2}, pages = {62-66}, year = {2016} }
RIS	TY - JOUR AU - Ghasemi M AU - Jaami R AU - Alleyassin A AU - Ansarimoghaddam A TI - The Value of Urea, Creatinine, Prolactin, and Beta Sub-Unit of Human Chorionic Gonadotropin of Vaginal Fluid in the Diagnosis of Premature Preterm Rupture of Membranes in Pregnancy; [Gebelikte Premature Preterm Membran Rupturu Tanisinda Vajinal Sivida Ure, Kreatinin, Prolaktin Ve Beta-Insan Koryonik Gonadotropinin Degeri] JO - Turkish Journal of Obstetrics and Gynecology VL - 13 IS - 2 SP - 62 EP - 66 PY - 2016 ER -

Style

Citing Format

MLA

Ghasemi M, et al.. "The Value of Urea, Creatinine, Prolactin, and Beta Sub-Unit of Human Chorionic Gonadotropin of Vaginal Fluid in the Diagnosis of Premature Preterm Rupture of Membranes in Pregnancy; [Gebelikte Premature Preterm Membran Rupturu Tanisinda Vajinal Sivida Ure, Kreatinin, Prolaktin Ve Beta-Insan Koryonik Gonadotropinin Degeri]." Turkish Journal of Obstetrics and Gynecology, vol. 13, no. 2, 2016, pp. 62-66.

APA

Ghasemi M, Jaami R, Alleyassin A, Ansarimoghaddam A (2016). The Value of Urea, Creatinine, Prolactin, and Beta Sub-Unit of Human Chorionic Gonadotropin of Vaginal Fluid in the Diagnosis of Premature Preterm Rupture of Membranes in Pregnancy; [Gebelikte Premature Preterm Membran Rupturu Tanisinda Vajinal Sivida Ure, Kreatinin, Prolaktin Ve Beta-Insan Koryonik Gonadotropinin Degeri]. Turkish Journal of Obstetrics and Gynecology, 13(2), 62-66.

Chicago

Ghasemi M, Jaami R, Alleyassin A, Ansarimoghaddam A. "The Value of Urea, Creatinine, Prolactin, and Beta Sub-Unit of Human Chorionic Gonadotropin of Vaginal Fluid in the Diagnosis of Premature Preterm Rupture of Membranes in Pregnancy; [Gebelikte Premature Preterm Membran Rupturu Tanisinda Vajinal Sivida Ure, Kreatinin, Prolaktin Ve Beta-Insan Koryonik Gonadotropinin Degeri]." Turkish Journal of Obstetrics and Gynecology 13, no. 2 (2016): 62-66.

Harvard

Ghasemi M et al. (2016) 'The Value of Urea, Creatinine, Prolactin, and Beta Sub-Unit of Human Chorionic Gonadotropin of Vaginal Fluid in the Diagnosis of Premature Preterm Rupture of Membranes in Pregnancy; [Gebelikte Premature Preterm Membran Rupturu Tanisinda Vajinal Sivida Ure, Kreatinin, Prolaktin Ve Beta-Insan Koryonik Gonadotropinin Degeri]', Turkish Journal of Obstetrics and Gynecology, 13(2), pp. 62-66.

Vancouver

Ghasemi M, Jaami R, Alleyassin A, Ansarimoghaddam A. The Value of Urea, Creatinine, Prolactin, and Beta Sub-Unit of Human Chorionic Gonadotropin of Vaginal Fluid in the Diagnosis of Premature Preterm Rupture of Membranes in Pregnancy; [Gebelikte Premature Preterm Membran Rupturu Tanisinda Vajinal Sivida Ure, Kreatinin, Prolaktin Ve Beta-Insan Koryonik Gonadotropinin Degeri]. Turkish Journal of Obstetrics and Gynecology. 2016;13(2):62-66.

BibTex

@article{ author = {Ghasemi M and Jaami R and Alleyassin A and Ansarimoghaddam A}, title = {The Value of Urea, Creatinine, Prolactin, and Beta Sub-Unit of Human Chorionic Gonadotropin of Vaginal Fluid in the Diagnosis of Premature Preterm Rupture of Membranes in Pregnancy; [Gebelikte Premature Preterm Membran Rupturu Tanisinda Vajinal Sivida Ure, Kreatinin, Prolaktin Ve Beta-Insan Koryonik Gonadotropinin Degeri]}, journal = {Turkish Journal of Obstetrics and Gynecology}, volume = {13}, number = {2}, pages = {62-66}, year = {2016} }

RIS

TY - JOUR
AU - Ghasemi M
AU - Jaami R
AU - Alleyassin A
AU - Ansarimoghaddam A
TI - The Value of Urea, Creatinine, Prolactin, and Beta Sub-Unit of Human Chorionic Gonadotropin of Vaginal Fluid in the Diagnosis of Premature Preterm Rupture of Membranes in Pregnancy; [Gebelikte Premature Preterm Membran Rupturu Tanisinda Vajinal Sivida Ure, Kreatinin, Prolaktin Ve Beta-Insan Koryonik Gonadotropinin Degeri]
JO - Turkish Journal of Obstetrics and Gynecology
VL - 13
IS - 2
SP - 62
EP - 66
PY - 2016
ER -

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