Optic Nerve Sheath Diameter in Predicting the Neurological Outcomes of Cardiac Arrest Survivors: A Systematic Review and Meta-Analysis

Optic Nerve Sheath Diameter in Predicting the Neurological Outcomes of Cardiac Arrest Survivors: A Systematic Review and Meta-Analysis Publisher

Khouzani PJ ; Rahmani E ; Rezaei M ; Benam SP ; Moghadam Fard AM ; Amanibeni R ; Daneshvar M ; Sarnaghy FJ ; Goodarzi NM ; Azar RA ; Mirbolook A ; Bashghareh P ; Bibak E ; Goodarzi B Show All Authors

Khouzani PJ
Rahmani E
Rezaei M
Benam SP
Moghadam Fard AM
Amanibeni R
Daneshvar M
Sarnaghy FJ
Goodarzi NM
Azar RA
Mirbolook A
Bashghareh P
Bibak E
Goodarzi B
Salarinezhad Z
Zahedpasha R
Hajizaman M
Rahmani NP
Darvishi A
Hadizadeh A
Zandi F
Azizi A
Naderi A
Hosseini SS
Sanjary A
Virsoudi MM
Afshang H
Mirabdali S
Fathalian N
Momeni P
Valizade M
Nozari F
Ghorbani H
Mohammadzadeh S
Sajadi SK
Abdollahi A
Farrokhi M

Source: Archives of Academic Emergency Medicine Published:2025

Abstract

Introduction: Previous studies have investigated different methods for estimating neurological outcomes after cardiac arrest. However, there is still much uncertainty about using optic nerve sheath diameter (ONSD) measurement as an indirect method for predicting neurological outcomes following cardiac arrest. In this meta-analysis, we aimed to investigate the value of ONSD for predicting the neurological outcomes of cardiac arrest survivors. Methods: We comprehensively performed a systematic search in three main electronic databases, including Scopus, Medline, and Web of Science Cochrane, from inception to August 2024. Based on the heterogeneity evaluation results, fixed or random effects models were used to estimate the pooled diagnostic parameters. Meta-regressions were performed for subgroup analysis. Results: The pooled sensitivity and specificity of ONSD for predicting the neurological outcomes were 0.56 (95% CI, 0.35–0.74) and 0.92 (95% CI, 0.85–0.96), respectively. Meta-regression revealed that as the cutoff level of ONSD increases, the sensitivity significantly decreases (P < 0.01), while the specificity significantly increases (P = 0.01). Furthermore, meta-regression analysis revealed that ONSD measurement using CT scans is significantly associated with lower sensitivity and higher specificity compared to ultrasound (P = 0.009 and P = 0.01). Conclusion: Our meta-analysis showed that ONSD has low sensitivity and high specificity for predicting neurological outcomes in survivors of cardiac arrest. However, since the cut-off values and methods of ONSD measurement affect its predictive performance, further studies will be required to standardize these factors to achieve optimal predictive parameters. © 2025 Elsevier B.V., All rights reserved.

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Style	Citing Format
MLA	Khouzani PJ, et al.. "Optic Nerve Sheath Diameter in Predicting the Neurological Outcomes of Cardiac Arrest Survivors: A Systematic Review and Meta-Analysis." Archives of Academic Emergency Medicine, vol. 13, no. 1, 2025, pp. -.
APA	Khouzani PJ, Rahmani E, Rezaei M, Benam SP, Moghadam Fard AM, Amanibeni R, Daneshvar M, Sarnaghy FJ, Goodarzi NM, Azar RA, Mirbolook A, Bashghareh P, Bibak E, Goodarzi B, Salarinezhad Z, Zahedpasha R, Hajizaman M, Rahmani NP, Darvishi A, ... Farrokhi M (2025). Optic Nerve Sheath Diameter in Predicting the Neurological Outcomes of Cardiac Arrest Survivors: A Systematic Review and Meta-Analysis. Archives of Academic Emergency Medicine, 13(1), -.
Chicago	Khouzani PJ, Rahmani E, Rezaei M, Benam SP, Moghadam Fard AM, Amanibeni R, Daneshvar M, et al.. "Optic Nerve Sheath Diameter in Predicting the Neurological Outcomes of Cardiac Arrest Survivors: A Systematic Review and Meta-Analysis." Archives of Academic Emergency Medicine 13, no. 1 (2025): -.
Harvard	Khouzani PJ et al. (2025) 'Optic Nerve Sheath Diameter in Predicting the Neurological Outcomes of Cardiac Arrest Survivors: A Systematic Review and Meta-Analysis', Archives of Academic Emergency Medicine, 13(1), pp. -.
Vancouver	Khouzani PJ, Rahmani E, Rezaei M, Benam SP, Moghadam Fard AM, Amanibeni R, et al.. Optic Nerve Sheath Diameter in Predicting the Neurological Outcomes of Cardiac Arrest Survivors: A Systematic Review and Meta-Analysis. Archives of Academic Emergency Medicine. 2025;13(1):-.
BibTex	@article{ author = {Khouzani PJ and Rahmani E and Rezaei M and Benam SP and Moghadam Fard AM and Amanibeni R and Daneshvar M and Sarnaghy FJ and Goodarzi NM and Azar RA and Mirbolook A and Bashghareh P and Bibak E and Goodarzi B and Salarinezhad Z and Zahedpasha R and Hajizaman M and Rahmani NP and Darvishi A and Hadizadeh A and Zandi F and Azizi A and Naderi A and Hosseini SS and Sanjary A and Virsoudi MM and Afshang H and Mirabdali S and Fathalian N and Momeni P and Valizade M and Nozari F and Ghorbani H and Mohammadzadeh S and Sajadi SK and Abdollahi A and Farrokhi M}, title = {Optic Nerve Sheath Diameter in Predicting the Neurological Outcomes of Cardiac Arrest Survivors: A Systematic Review and Meta-Analysis}, journal = {Archives of Academic Emergency Medicine}, volume = {13}, number = {1}, pages = {-}, year = {2025} }
RIS	TY - JOUR AU - Khouzani PJ AU - Rahmani E AU - Rezaei M AU - Benam SP AU - Moghadam Fard AM AU - Amanibeni R AU - Daneshvar M AU - Sarnaghy FJ AU - Goodarzi NM AU - Azar RA AU - Mirbolook A AU - Bashghareh P AU - Bibak E AU - Goodarzi B AU - Salarinezhad Z AU - Zahedpasha R AU - Hajizaman M AU - Rahmani NP AU - Darvishi A AU - Hadizadeh A AU - Zandi F AU - Azizi A AU - Naderi A AU - Hosseini SS AU - Sanjary A AU - Virsoudi MM AU - Afshang H AU - Mirabdali S AU - Fathalian N AU - Momeni P AU - Valizade M AU - Nozari F AU - Ghorbani H AU - Mohammadzadeh S AU - Sajadi SK AU - Abdollahi A AU - Farrokhi M TI - Optic Nerve Sheath Diameter in Predicting the Neurological Outcomes of Cardiac Arrest Survivors: A Systematic Review and Meta-Analysis JO - Archives of Academic Emergency Medicine VL - 13 IS - 1 SP - EP - PY - 2025 ER -

Style

Citing Format

MLA

Khouzani PJ, et al.. "Optic Nerve Sheath Diameter in Predicting the Neurological Outcomes of Cardiac Arrest Survivors: A Systematic Review and Meta-Analysis." Archives of Academic Emergency Medicine, vol. 13, no. 1, 2025, pp. -.

APA

Khouzani PJ, Rahmani E, Rezaei M, Benam SP, Moghadam Fard AM, Amanibeni R, Daneshvar M, Sarnaghy FJ, Goodarzi NM, Azar RA, Mirbolook A, Bashghareh P, Bibak E, Goodarzi B, Salarinezhad Z, Zahedpasha R, Hajizaman M, Rahmani NP, Darvishi A, ... Farrokhi M (2025). Optic Nerve Sheath Diameter in Predicting the Neurological Outcomes of Cardiac Arrest Survivors: A Systematic Review and Meta-Analysis. Archives of Academic Emergency Medicine, 13(1), -.

Chicago

Khouzani PJ, Rahmani E, Rezaei M, Benam SP, Moghadam Fard AM, Amanibeni R, Daneshvar M, et al.. "Optic Nerve Sheath Diameter in Predicting the Neurological Outcomes of Cardiac Arrest Survivors: A Systematic Review and Meta-Analysis." Archives of Academic Emergency Medicine 13, no. 1 (2025): -.

Harvard

Khouzani PJ et al. (2025) 'Optic Nerve Sheath Diameter in Predicting the Neurological Outcomes of Cardiac Arrest Survivors: A Systematic Review and Meta-Analysis', Archives of Academic Emergency Medicine, 13(1), pp. -.

Vancouver

Khouzani PJ, Rahmani E, Rezaei M, Benam SP, Moghadam Fard AM, Amanibeni R, et al.. Optic Nerve Sheath Diameter in Predicting the Neurological Outcomes of Cardiac Arrest Survivors: A Systematic Review and Meta-Analysis. Archives of Academic Emergency Medicine. 2025;13(1):-.

BibTex

@article{ author = {Khouzani PJ and Rahmani E and Rezaei M and Benam SP and Moghadam Fard AM and Amanibeni R and Daneshvar M and Sarnaghy FJ and Goodarzi NM and Azar RA and Mirbolook A and Bashghareh P and Bibak E and Goodarzi B and Salarinezhad Z and Zahedpasha R and Hajizaman M and Rahmani NP and Darvishi A and Hadizadeh A and Zandi F and Azizi A and Naderi A and Hosseini SS and Sanjary A and Virsoudi MM and Afshang H and Mirabdali S and Fathalian N and Momeni P and Valizade M and Nozari F and Ghorbani H and Mohammadzadeh S and Sajadi SK and Abdollahi A and Farrokhi M}, title = {Optic Nerve Sheath Diameter in Predicting the Neurological Outcomes of Cardiac Arrest Survivors: A Systematic Review and Meta-Analysis}, journal = {Archives of Academic Emergency Medicine}, volume = {13}, number = {1}, pages = {-}, year = {2025} }

RIS

TY - JOUR
AU - Khouzani PJ
AU - Rahmani E
AU - Rezaei M
AU - Benam SP
AU - Moghadam Fard AM
AU - Amanibeni R
AU - Daneshvar M
AU - Sarnaghy FJ
AU - Goodarzi NM
AU - Azar RA
AU - Mirbolook A
AU - Bashghareh P
AU - Bibak E
AU - Goodarzi B
AU - Salarinezhad Z
AU - Zahedpasha R
AU - Hajizaman M
AU - Rahmani NP
AU - Darvishi A
AU - Hadizadeh A
AU - Zandi F
AU - Azizi A
AU - Naderi A
AU - Hosseini SS
AU - Sanjary A
AU - Virsoudi MM
AU - Afshang H
AU - Mirabdali S
AU - Fathalian N
AU - Momeni P
AU - Valizade M
AU - Nozari F
AU - Ghorbani H
AU - Mohammadzadeh S
AU - Sajadi SK
AU - Abdollahi A
AU - Farrokhi M
TI - Optic Nerve Sheath Diameter in Predicting the Neurological Outcomes of Cardiac Arrest Survivors: A Systematic Review and Meta-Analysis
JO - Archives of Academic Emergency Medicine
VL - 13
IS - 1
SP -
EP -
PY - 2025
ER -

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