Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
A Case of Non-Compacted Left Ventricle and Lung Squamous Cell Carcinoma With Multiple Left Ventricular Clots



Alizadehasl A1 ; Parsa NA2 ; Mousavi SA3 ; Fumani HK3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Cardio-Oncology Department and Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Science, Tehran, Iran
  2. 2. Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Science, Tehran, Iran
  3. 3. Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Iranian Heart Journal Published:2023

Abstract

Left ventricular (LV) non-compaction is a genetic disease which might result in heart failure, arrhythmias, and thromboembolic events. Nonetheless, other diseases and drugs or toxins like chemotherapy agents can also simulate or exacerbate this phenotype and accelerate systolic dysfunction. Moreover, cancer and receiving chemotherapy agents are procoagulant states leading to venous, arterial, and intracardiac thromboses. Case: A 62-year-old man with a history of lung squamous cell carcinoma from 4 months earlier and non-compacted LV presented with dyspnea, severe LV systolic dysfunction, and multiple large LV clots. Discussion: Non-compacted LV can be a risk factor to exacerbate the cardiotoxicity of cancer therapeutics and lead to severe LV systolic failure. Additionally, severe LV systolic dysfunction, advanced stages of the lung cancer, the hypercoagulable state of cancer, and chemotherapy drugs like platinum agents could result in the formation of multiple large clots in the LV. (Iranian Heart Journal 2023; 24(2): 94-99). © 2023, Iranian Heart Association. All rights reserved.