Effect of Adding Magnesium Sulphate to Epidural Bupivacaine and Morphine on Post-Thoracotomy Pain Management: A Randomized, Double-Blind, Clinical Trial

Effect of Adding Magnesium Sulphate to Epidural Bupivacaine and Morphine on Post-Thoracotomy Pain Management: A Randomized, Double-Blind, Clinical Trial Publisher Pubmed

Farzanegan B¹ ; Zangi M¹ ; Saeedi K² ; Khalili A¹ ; Rajabi M² ; Jahangirifard A³ ; Emami H⁴ ; Mahboobipour AA⁵ ; Baniasadi S¹

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1. Tracheal Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Department of Clinical Pharmacy, Faculty of Pharmacy, Islamic Azad University, Pharmaceutical Sciences Branch, Tehran, Iran
3. Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
4. Tobacco Prevention and Control Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
5. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Basic and Clinical Pharmacology and Toxicology Published:2018

Abstract

Post-thoracotomy pain is very severe and may cause pulmonary complications. Thoracic epidural analgesia can greatly decrease the pain experience and its consequences. However, finding new methods to decrease the amount of administered opioids is an important issue of research. We aimed to evaluate the effect of adding epidural magnesium sulphate to bupivacaine and morphine on pain control and the amount of opioid consumption after thoracotomy. Eighty patients undergoing thoracotomy at a tertiary cardiothoracic referral centre were enrolled in a randomized, double-blind trial. Patients were randomly allocated to two groups. Bupivacaine (12.5 mg) and morphine (2 mg) were administered epidurally to all patients at the end of operation. Patients in the magnesium (Mg) group received epidural magnesium sulphate (50 mg), and patients in the control (C) group received normal saline as an adjuvant. Visual analogue scale (VAS) score and the amount of morphine consumption were measured during 24 hr post-operation. Thirty-nine patients in the Mg group and 41 patients in the C group completed the study. Patients in the Mg group had significantly less VAS score at recovery time (p < 0.05), 2 hr (p < 0.01) and 4 hr (p < 0.05) after surgery. The patient-controlled analgesia pump was started earlier in the C group than in the Mg group (p < 0.05). The amount of morphine needed in the Mg group was significantly lower than in the C group (5.64 ± 1.69 mg/24 hr versus 8.44 ± 3.98 mg/24 hr; p < 0.001). Pruritus was seen in the C group (9.7%) and absent in the Mg group (p < 0.05). Co-administration of magnesium sulphate with bupivacaine and morphine for thoracic epidural analgesia after thoracotomy leads to a reduction in post-operative pain score and the need for opioid administration. © 2018 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society)

2. Effect of Low-Dose (Single-Dose) Magnesium Sulfate on Postoperative Analgesia in Hysterectomy Patients Receiving Balanced General Anesthesia, Anesthesiology Research and Practice (2015)

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Arman Taheri (1)

Style	Citing Format
MLA	Farzanegan B, et al.. "Effect of Adding Magnesium Sulphate to Epidural Bupivacaine and Morphine on Post-Thoracotomy Pain Management: A Randomized, Double-Blind, Clinical Trial." Basic and Clinical Pharmacology and Toxicology, vol. 123, no. 5, 2018, pp. 602-606.
APA	Farzanegan B, Zangi M, Saeedi K, Khalili A, Rajabi M, Jahangirifard A, Emami H, Mahboobipour AA, Baniasadi S (2018). Effect of Adding Magnesium Sulphate to Epidural Bupivacaine and Morphine on Post-Thoracotomy Pain Management: A Randomized, Double-Blind, Clinical Trial. Basic and Clinical Pharmacology and Toxicology, 123(5), 602-606.
Chicago	Farzanegan B, Zangi M, Saeedi K, Khalili A, Rajabi M, Jahangirifard A, Emami H, Mahboobipour AA, Baniasadi S. "Effect of Adding Magnesium Sulphate to Epidural Bupivacaine and Morphine on Post-Thoracotomy Pain Management: A Randomized, Double-Blind, Clinical Trial." Basic and Clinical Pharmacology and Toxicology 123, no. 5 (2018): 602-606.
Harvard	Farzanegan B et al. (2018) 'Effect of Adding Magnesium Sulphate to Epidural Bupivacaine and Morphine on Post-Thoracotomy Pain Management: A Randomized, Double-Blind, Clinical Trial', Basic and Clinical Pharmacology and Toxicology, 123(5), pp. 602-606.
Vancouver	Farzanegan B, Zangi M, Saeedi K, Khalili A, Rajabi M, Jahangirifard A, et al.. Effect of Adding Magnesium Sulphate to Epidural Bupivacaine and Morphine on Post-Thoracotomy Pain Management: A Randomized, Double-Blind, Clinical Trial. Basic and Clinical Pharmacology and Toxicology. 2018;123(5):602-606.
BibTex	@article{ author = {Farzanegan B and Zangi M and Saeedi K and Khalili A and Rajabi M and Jahangirifard A and Emami H and Mahboobipour AA and Baniasadi S}, title = {Effect of Adding Magnesium Sulphate to Epidural Bupivacaine and Morphine on Post-Thoracotomy Pain Management: A Randomized, Double-Blind, Clinical Trial}, journal = {Basic and Clinical Pharmacology and Toxicology}, volume = {123}, number = {5}, pages = {602-606}, year = {2018} }
RIS	TY - JOUR AU - Farzanegan B AU - Zangi M AU - Saeedi K AU - Khalili A AU - Rajabi M AU - Jahangirifard A AU - Emami H AU - Mahboobipour AA AU - Baniasadi S TI - Effect of Adding Magnesium Sulphate to Epidural Bupivacaine and Morphine on Post-Thoracotomy Pain Management: A Randomized, Double-Blind, Clinical Trial JO - Basic and Clinical Pharmacology and Toxicology VL - 123 IS - 5 SP - 602 EP - 606 PY - 2018 ER -

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