Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Insights on Mpox Virus Infection Immunopathogenesis Publisher Pubmed



Saghazadeh A1, 2 ; Rezaei N1, 3, 4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Systematic Review and Meta-analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  3. 3. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran

Source: Reviews in Medical Virology Published:2023


Abstract

An immunocompromised status has been associated with more odds of being infected with Mpox virus (MPXV) and progressing to severe disease. This aligns with the importance of immune competence for MPXV control and clearance. We and others have previously reviewed parallels between MPXV and other viruses belonging to the Poxviridae in affecting the immune system. This article reviews studies providing direct evidence of the MPXV-immune interactions. The wide-ranging effects of MPXV on the immune system, from stimulation to modulation to memory, are broadly categorised, followed by a detailing of these effects on the immune cells and molecules, including natural killer cells, macrophages, neutrophils, lymphocytes, cytokines, interferons, chemokines, and complement. © 2023 John Wiley & Sons Ltd.
Related Docs
View other Related Docs
1. Progress and Prospects on Vaccine Development Against Monkeypox Infection, Microbial Pathogenesis (2023)
2. Human Monkeypox (Hmpxv) Re-Emergence: Host Immunity Status and Current Vaccines Landscape, Journal of Medical Virology (2023)
3. Monkeypox Virus Diagnosis and Laboratory Testing, Reviews in Medical Virology (2023)
4. Mechanisms of Immune Evasion of Monkeypox Virus, Frontiers in Microbiology (2023)
5. Demographic, Epidemiologic, and Clinical Characteristics of Human Monkeypox Disease Pre- and Post-2022 Outbreaks: A Systematic Review and Meta-Analysis, Biomedicines (2023)
6. Investigation of the Effects of Previous Smallpox Vaccination Against Monkeypox Disease: A Systemic Review, Journal of Applied Biotechnology Reports (2023)
7. The Effective Factors in Human-Specific Tropism and Viral Pathogenicity in Orthopoxviruses, Cell Biology International (2023)
8. A Systematic Review and Clinical Atlas on Mucocutaneous Presentations of the Current Monkeypox Outbreak: With a Comprehensive Approach to All Dermatologic and Nondermatologic Aspects of the New and Previous Monkeypox Outbreaks, Journal of Medical Virology (2023)
Experts (# of related papers)
Nima Rezaei (2)
Zeinab Aryanian (1)
Other Related Docs
9. Inborn Errors of Immunity and Worries During the Monkeypox Outbreak, Journal of Medical Virology (2023)
10. Poxviruses and the Immune System: Implications for Monkeypox Virus, International Immunopharmacology (2022)