Remdesivir in Solid Organ Transplant Recipients With Covid-19: A Systematic Review and Meta-Analysis Publisher



Navidi Z¹ ; Moghadam SHP¹ ; Iravani MM² ; Orandi A³ ; Orandi A³ ; Ghazi SF⁵ ; Fallah E⁶ ; Malekabad ES⁷ ; Khorramnia S¹ Show Affiliations
Source: Clinical Transplantation and Research Published:2024

Abstract

Background: The use of remdesivir in solid organ transplant recipients (SOTRs) with coronavirus disease 2019 (COVID-19) has been studied. The present systematic review and analysis aimed to assess its effectiveness in this population. Methods: A comprehensive search of PubMed, Cochrane Library, Web of Science, Embase, medRxiv, and Google Scholar was conducted to identify relevant articles published up to April 2024. The quality of the included studies was evaluated using the Cochrane assessment tool. Data analysis was performed using the Comprehensive Meta-Analysis software ver. 3.0. Results: The meta-analysis included seven eligible retrospective studies, involving a total of 574 SOTRs. The findings indicated no significant differences in mortality rate (odds ratio [OR], 1.19; 95% confidence interval [CI], 0.59–2.39), hospitalization rate (OR, 0.69; 95% CI, 0.10–4.79), need for mechanical ventilation (OR, 0.98; 95% CI, 0.44–2.18), or need for oxygen therapy (OR, 3.73; 95% CI, 0.75–18.34) between the groups that received remdesivir and those that did not. However, a statistically significant difference was observed in the rate of intensive care unit admissions between the two groups (OR, 2.39; 95% CI, 1.24–4.57). Conclusions: Our meta-analysis found that remdesivir offers no clinical benefits to SOTRs infected with COVID-19. Additional high-quality research is required to assess the potential clinical advantages of remdesivir for SOTRs with COVID-19. © The Korean Society for Transplantation.