Fludarabine-Based Reduced-Intensity Conditioning Regimen for Hematopoietic Stem Cell Transplantation in Pediatric Patient With Il10 Receptor Deficiency

Fludarabine-Based Reduced-Intensity Conditioning Regimen for Hematopoietic Stem Cell Transplantation in Pediatric Patient With Il10 Receptor Deficiency Publisher Pubmed

Kheder M^{1, 2} ; Behfar M¹ ; Farajifard H^{1, 3} ; Ali T^{1, 2} ; Hkima Abou Fakher F^{1, 2} ; Hamidieh AA¹

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1. Pediatric Cell Therapy Research Center, Tehran University of Medical Sciences, Tehran, Iran
2. Pediatric Stem Cell Transplant Department, Childrenâ€™s Hospital, Damascus University, Damascus, Syrian Arab Republic
3. Immunology-Microbiology Department, Qom University of Medical Sciences and Health Services, Qom, Iran

Source: Pediatric Transplantation Published:2021

Abstract

IL-10R deficiency results in severe immune dysregulation. Herein, we describe the successful treatment of a girl aged 6.8 years with IL10R deficiency by using RIC prior to HSCT from a matched unrelated donor. The regimen was well tolerated, the engraftment was completely attained. On a follow-up of 7 months, the patient remained in good medical conditions with full donor chimerism. All complications before HSCT were completely resolved and her growth was accelerated. RIC regimen might be adequate to induce permanent engraftment and avoid severe organ toxicity in IL-10R deficiency patients. © 2020 Wiley Periodicals LLC

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Amir Ali Hamidieh (6)

Maryam Behfar (5)

Style	Citing Format
MLA	Kheder M, et al.. "Fludarabine-Based Reduced-Intensity Conditioning Regimen for Hematopoietic Stem Cell Transplantation in Pediatric Patient With Il10 Receptor Deficiency." Pediatric Transplantation, vol. 25, no. 2, 2021, pp. -.
APA	Kheder M, Behfar M, Farajifard H, Ali T, Hkima Abou Fakher F, Hamidieh AA (2021). Fludarabine-Based Reduced-Intensity Conditioning Regimen for Hematopoietic Stem Cell Transplantation in Pediatric Patient With Il10 Receptor Deficiency. Pediatric Transplantation, 25(2), -.
Chicago	Kheder M, Behfar M, Farajifard H, Ali T, Hkima Abou Fakher F, Hamidieh AA. "Fludarabine-Based Reduced-Intensity Conditioning Regimen for Hematopoietic Stem Cell Transplantation in Pediatric Patient With Il10 Receptor Deficiency." Pediatric Transplantation 25, no. 2 (2021): -.
Harvard	Kheder M et al. (2021) 'Fludarabine-Based Reduced-Intensity Conditioning Regimen for Hematopoietic Stem Cell Transplantation in Pediatric Patient With Il10 Receptor Deficiency', Pediatric Transplantation, 25(2), pp. -.
Vancouver	Kheder M, Behfar M, Farajifard H, Ali T, Hkima Abou Fakher F, Hamidieh AA. Fludarabine-Based Reduced-Intensity Conditioning Regimen for Hematopoietic Stem Cell Transplantation in Pediatric Patient With Il10 Receptor Deficiency. Pediatric Transplantation. 2021;25(2):-.
BibTex	@article{ author = {Kheder M and Behfar M and Farajifard H and Ali T and Hkima Abou Fakher F and Hamidieh AA}, title = {Fludarabine-Based Reduced-Intensity Conditioning Regimen for Hematopoietic Stem Cell Transplantation in Pediatric Patient With Il10 Receptor Deficiency}, journal = {Pediatric Transplantation}, volume = {25}, number = {2}, pages = {-}, year = {2021} }
RIS	TY - JOUR AU - Kheder M AU - Behfar M AU - Farajifard H AU - Ali T AU - Hkima Abou Fakher F AU - Hamidieh AA TI - Fludarabine-Based Reduced-Intensity Conditioning Regimen for Hematopoietic Stem Cell Transplantation in Pediatric Patient With Il10 Receptor Deficiency JO - Pediatric Transplantation VL - 25 IS - 2 SP - EP - PY - 2021 ER -

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