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Incidence of Hiv and Hcv in People Who Inject Drugs: A Systematic and Meta-Analysis Review Protocol Publisher Pubmed



Sharhani A1 ; Jorjoran Shushtari Z2 ; Rahmani A3 ; Armoon B4 ; Noroozi M2 ; Ahounbar E5 ; Karimi SE6 ; Higgs P7, 8
Authors
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Authors Affiliations
  1. 1. Department of Epidemiology and Biostatistics, Public Health Faculty, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  2. 2. Social Determinants of Health Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
  3. 3. Nursing and Midwifery Care Research Center, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh, Iran
  5. 5. Substance Abuse and Dependence Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
  6. 6. Social Determinants of Health Research Center, Health Management and Safety Promotion Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran
  7. 7. Department of Public Health, La Trobe University, Plenty Rd and Kingsbury Dr, Bundoora, 3086, VIC, Australia
  8. 8. Behaviours and Health Risks Program, Burnet Institute, 85 Commercial Road, Melbourne, 3004, VIC, Australia

Source: BMJ Open Published:2021


Abstract

Introduction HIV and hepatitis C virus (HCV) are major health concerns globally. This systematic review and meta-analysis protocol study aims to estimate the incidence of HIV and HCV among people who inject drugs (PWIDs) by reviewing studies that have applied mathematical modelling. The primary purpose of this systematic review is to identify and review mathematical modelling studies of HIV and HCV incidence in PWIDs. Methods and analysis cohort, cross-sectional and clinical trial studies conducted to estimate the incidence of HIV and HCV based on mathematical models or have evaluated the effectiveness of mathematical models will be considered for inclusion in the review. A comprehensive search applying a Cochrane approach will be used to identify relevant primary studies, published between January 2000 and July 2020, and indexed in PubMed, EMBASE, Opengrey, WOS, SCOPUS and Cochrane Library with no restriction on language. This protocol was prepared according to the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). Study selection and data extraction will be performed by two independent reviewers. Assessment of risk of bias will be implemented using forms of the Critical Appraisal Skills Programme. Publication bias will be assessed by funnel plots, Begg's and Egger's tests. A meta-analysis will be conducted to answer the first research question, 'What is the incidence of HIV and HCV when applying mathematical model in PWID?'. Clinical heterogeneity will be assessed by looking at the characteristics of participants, method of diagnosis and case definitions in the included primary studies. In addition, subgroup analyses will be conducted for population and secondary outcomes. Ethics and dissemination There are no ethical issues related to this study. The findings will be published in peer-reviewed scientific journals and presented at international and national conferences. PROSPERO registration number CRD42019126476. ©
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