Sentinel Gene Within Cell Territory and Molecular Platforms in Cancer: Methylation Diversity of P53 Gene in Brain Tumors Publisher



Mehdipour P¹ ; Karami F¹ Show Affiliations
Source: Epigenetics Territory and Cancer Published:2015

Abstract

TP53 is the most important tumor suppressor gene which plays critical functions to avoid tumor progression and development through inducing the DNA repair pathways or cell cycle arrest. High frequency of p53 gene aberrations in various types of cancer has relied on its significant roles in prevention of arising tumors. However, the effect of promoter methylation of this gene on its protein expression and function remains unclear and there is a strong controversy among various investigations especially those studies performed on brain tumors. TP53 may be the most frequent gene which was studied in different aspects of cancer biology and therefore a considerable literature is available. In this chapter, we tried to provide a brief explanation about the basic knowledge which was found in investigations either at p53 gene- or protein- level and then its function and aberrations in various cancers will be described. Finally, we will discuss about the methylation status of p53 gene promoter in different types of cancers with emphasizing on brain tumors. © Springer Science+Business Media Dordrecht 2015.