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Cytokine-Induced Killer Cells Mediated Pathways in the Treatment of Colorectal Cancer Publisher Pubmed



Fayyaz F1, 2 ; Yazdanpanah N3, 4, 5 ; Rezaei N3, 4, 6
Authors
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Authors Affiliations
  1. 1. Students’ Research Committee, Alborz University of Medical Sciences, Alborz, Iran
  2. 2. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Alborz, Iran
  3. 3. Research Center for Immunodeficiencies, Children’s Medical Center Hospital, Tehran University of Medical, Dr. Qarib St, Keshavarz Blvd, Tehran, 14194, Iran
  4. 4. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  5. 5. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Cell Communication and Signaling Published:2022


Abstract

Cytokine-induced killer (CIK) cell therapy is a type of adoptive immunotherapy that due to its high proliferation rate and anti-tumor characteristics, is being investigated to treat various solid tumors. Since advanced colorectal cancer (CRC) has high mortality and poor survival rates, and the efficacy of chemotherapy and radiotherapy is limited in treatment, the application of CIK cell therapy in CRC has been evaluated in numerous studies. This review aims to summarize the clinical studies that investigated the safety and clinical efficacy of CIK cell therapy in CRC. Therefore, 1,969 enrolled CRC patients in the clinical trials, of which 842 patients received CIK cells in combination with chemotherapy with or without dendritic cell (DC) infusions, were included in the present review. Furthermore, the signaling pathways involved in CIK cell therapy and novel methods for improving migration abilities are discussed. [MediaObject not available: see fulltext.] © 2022, The Author(s).
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