Polymorphism in the 3′-Utr of Lif But Not in the Atf6b Gene Associates With Schizophrenia Susceptibility: A Case-Control Study and in Silico Analyses

Polymorphism in the 3′-Utr of Lif But Not in the Atf6b Gene Associates With Schizophrenia Susceptibility: A Case-Control Study and in Silico Analyses Publisher Pubmed

Moudi M¹ ; Sargazi S² ; Heidari Nia M² ; Saravani R^{2, 3} ; Shirvaliloo M^{4, 5} ; Shakiba M^{6, 7}

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1. Genetics of Non-Communicable Disease Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran
2. Cellular and Molecular Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran
3. Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
4. Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
5. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
6. Department of Psychiatry, Zahedan University of Medical Sciences, Zahedan, Iran
7. Psychosomatic Research Center, Imam Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Molecular Neuroscience Published:2020

Abstract

Schizophrenia (SCZ) is a multifactorial disorder caused by environmental and genetic factors. Studies have shown that various single-nucleotide polymorphisms (SNPs) in the binding sites of microRNAs contribute to the risk of developing SCZ. We aimed to investigate whether the variants located in the 3′-UTR region of LIF (rs929271T>G) and ATF6B (rs8283G>A) were associated with increased susceptibility to SCZ in a population from the south-east of Iran. In this case-control study, a total of 396 subjects were recruited. SNPs were genotyped via polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Genotyping results showed that the G allele of rs929271 significantly increased the risk of SCZ (OR = 1.58 95%CI = 1.19–2.10, p = 0.001). As for rs929271, the GG genotype of co-dominant (OR = 2.54 95%CI = 1.39–4.64, p = 0.002) and recessive (OR = 2.91 95%CI = 1.77–4.80, p < 0.001) models were strongly linked to SCZ. No significant differences were observed between rs8283 polymorphism and predisposition to SCZ. In silico analyses predicted that rs929271 might alter the binding sites of microRNAs, which was believed to have an unclear role in the development of SCZ. Moreover, rs929271 polymorphism changed the LIF-mRNA folding structure. These findings provide fine pieces of evidence regarding the possible effects of LIF polymorphism in the development of SCZ and regulation of the LIF gene targeted by microRNAs. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.

2. A Bioinformatics Approach to the Identification of Variants Associated With Type 1 and Type 2 Diabetes Mellitus That Reside in Functionally Validated Mirnas Binding Sites, Biochemical Genetics (2016)

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Style	Citing Format
MLA	Moudi M, et al.. "Polymorphism in the 3′-Utr of Lif But Not in the Atf6b Gene Associates With Schizophrenia Susceptibility: A Case-Control Study and in Silico Analyses." Journal of Molecular Neuroscience, vol. 70, no. 12, 2020, pp. 2093-2101.
APA	Moudi M, Sargazi S, Heidari Nia M, Saravani R, Shirvaliloo M, Shakiba M (2020). Polymorphism in the 3′-Utr of Lif But Not in the Atf6b Gene Associates With Schizophrenia Susceptibility: A Case-Control Study and in Silico Analyses. Journal of Molecular Neuroscience, 70(12), 2093-2101.
Chicago	Moudi M, Sargazi S, Heidari Nia M, Saravani R, Shirvaliloo M, Shakiba M. "Polymorphism in the 3′-Utr of Lif But Not in the Atf6b Gene Associates With Schizophrenia Susceptibility: A Case-Control Study and in Silico Analyses." Journal of Molecular Neuroscience 70, no. 12 (2020): 2093-2101.
Harvard	Moudi M et al. (2020) 'Polymorphism in the 3′-Utr of Lif But Not in the Atf6b Gene Associates With Schizophrenia Susceptibility: A Case-Control Study and in Silico Analyses', Journal of Molecular Neuroscience, 70(12), pp. 2093-2101.
Vancouver	Moudi M, Sargazi S, Heidari Nia M, Saravani R, Shirvaliloo M, Shakiba M. Polymorphism in the 3′-Utr of Lif But Not in the Atf6b Gene Associates With Schizophrenia Susceptibility: A Case-Control Study and in Silico Analyses. Journal of Molecular Neuroscience. 2020;70(12):2093-2101.
BibTex	@article{ author = {Moudi M and Sargazi S and Heidari Nia M and Saravani R and Shirvaliloo M and Shakiba M}, title = {Polymorphism in the 3′-Utr of Lif But Not in the Atf6b Gene Associates With Schizophrenia Susceptibility: A Case-Control Study and in Silico Analyses}, journal = {Journal of Molecular Neuroscience}, volume = {70}, number = {12}, pages = {2093-2101}, year = {2020} }
RIS	TY - JOUR AU - Moudi M AU - Sargazi S AU - Heidari Nia M AU - Saravani R AU - Shirvaliloo M AU - Shakiba M TI - Polymorphism in the 3′-Utr of Lif But Not in the Atf6b Gene Associates With Schizophrenia Susceptibility: A Case-Control Study and in Silico Analyses JO - Journal of Molecular Neuroscience VL - 70 IS - 12 SP - 2093 EP - 2101 PY - 2020 ER -

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