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Clinicopathological Features of Non-Metastatic Triple Negative Breast Cancer



Najafi S1 ; Mozaffari HR2, 3 ; Sadeghi M3, 4
Authors
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Authors Affiliations
  1. 1. Breast Cancer Research Centre, ACECR, Tehran, Iran
  2. 2. Department of Oral Medicine, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran
  3. 3. Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  4. 4. Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran

Source: Iranian Journal of Blood and Cancer Published:2017

Abstract

Background: Triple negative breast cancer (TNBC) is reported to be associated with a high risk of recurrence, poor overall survival (OS), and disease-free survival (DFS) rates. This study evaluated the clincopathological features and survival of non-metastatic TNBC women in the capital of Iran compared with other areas of the world. Methods: In a retrospective study, 119 women with TNBC based on the criteria were analyzed in this study during 2007-2015. A number of clinicopathological variables, OS and DFS were determined in all patients. The mean follow-up was 38 months, which 6 patients lost to follow-up and 16 died of the disease and therefore were censored from the study. Results: The mean age at diagnosis was 44.9 years (range: 21-85 years). 31.9% were older than 50 years. The 2-and 5-years OS rates were 96% and 88.1%, respectively; whereas, the 2-and 5-years DFS rates were 87% and 74.1%, respectively. Right breast tumor and lymph node involvement were more common in patients younger than 50 years, but vascular invasion was more observed in patients aged ≥50 years. There was no significant difference between menopause status, age and Ki-67 index for OS or DFS. Conclusion: The prevalence of TNBC was more common in women younger than 50 years. Ki-67 index, menopausal status and age could contribute to prognosis and survival of patients. © 2017, Iranian Pediatric Hematology and Oncology Society. All rights reserved.