“Oral Manifestations of Patients With Inherited Defect in Phagocyte Number or Function” a Systematic Review Publisher Pubmed



Ziaei H^{1, 2, 3} ; Tonkaboni A⁴ ; Shamshiri A⁵ ; Rezaei N^{2, 6, 7}
Source: Clinical Immunology Published:2021

Abstract

Introduction: Inherited phagocyte defects are one of the subgroups of primary immunodeficiency diseases (PIDs) with various clinical manifestations. As oral manifestations are common at the early ages, oral practitioners can have a special role in the early diagnosis. Materials and methods: A comprehensive search was conducted in this systematic review study and data of included studies were categorized into four subgroups of phagocyte defects, including congenital neutropenia, defects of motility, defects of respiratory burst, and other non-lymphoid defects. Results: Among all phagocyte defects, 12 disorders had reported data for oral manifestations in published articles. A total of 987 cases were included in this study. Periodontitis is one of the most common oral manifestations. Conclusion: There is a need to organize better collaboration between medical doctors and dentists to diagnose and treat patients with phagocyte defects. Regular dental visits and professional oral health care are recommended from the time of the first primary teeth eruption in newborns. © 2021 Elsevier Inc.