Nasal Air Puff Promotes Default Mode Network Activity in Mechanically Ventilated Comatose Patients: A Noninvasive Brain Stimulation Approach

Nasal Air Puff Promotes Default Mode Network Activity in Mechanically Ventilated Comatose Patients: A Noninvasive Brain Stimulation Approach Publisher Pubmed

Salimi M¹ ; Javadi AH^{2, 3} ; Nazari M^{4, 5, 6} ; Bamdad S⁷ ; Tabasi F^{1, 8} ; Parsazadegan T¹ ; Ayene F¹ ; Karimian M⁹ ; Gholamimahtaj L¹ ; Shadnia S¹⁰ ; Jamaati H⁹ ; Salimi A⁹ ; Raoufy MR^{1, 8}

Show Affiliations

1. Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
2. School of Psychology, University of Kent, Canterbury, United Kingdom
3. School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran
4. Electrical Engineering Department, Sharif University of Technology, Tehran, Iran
5. Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark
6. The Danish Research Institute of Translational Neuroscience (DANDRITE), Department of Biomedicine, Aarhus University, Aarhus, Denmark
7. Department of Biomedical Engineering, Faculty of Engineering, Shahed University, Tehran, Iran
8. Institute for Brain Sciences and Cognition, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
9. Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
10. Department of Clinical Toxicology, Excellence Center of Clinical Toxicology, Loghman Hakim Hospital Poison Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Neuromodulation Published:2022

Abstract

Objectives: Coma state and loss of consciousness are associated with impaired brain activity, particularly gamma oscillations, that integrate functional connectivity in neural networks, including the default mode network (DMN). Mechanical ventilation (MV) in comatose patients can aggravate brain activity, which has decreased in coma, presumably because of diminished nasal airflow. Nasal airflow, known to drive functional neural oscillations, synchronizing distant brain networks activity, is eliminated by tracheal intubation and MV. Hence, we proposed that rhythmic nasal air puffing in mechanically ventilated comatose patients may promote brain activity and improve network connectivity. Materials and Methods: We recorded electroencephalography (EEG) from 15 comatose patients (seven women) admitted to the intensive care unit because of opium poisoning and assessed the activity, complexity, and connectivity of the DMN before and during the nasal air-puff stimulation. Nasal cavity air puffing was done through a nasal cannula controlled by an electrical valve (open duration of 630 ms) with a frequency of 0.2 Hz (ie, 12 puff/min). Results: Our analyses demonstrated that nasal air puffing enhanced the power of gamma oscillations (30–100 Hz) in the DMN. In addition, we found that the coherence and synchrony between DMN regions were increased during nasal air puffing. Recurrence quantification and fractal dimension analyses revealed that EEG global complexity and irregularity, typically seen in wakefulness and conscious state, increased during rhythmic nasal air puffing. Conclusions: Rhythmic nasal air puffing, as a noninvasive brain stimulation method, opens a new window to modifying the brain connectivity integration in comatose patients. This approach may potentially influence comatose patients’ outcomes by increasing brain reactivity and network connectivity. © 2021 International Neuromodulation Society

2. Disrupted Resting-State Brain Functional Network in Methamphetamine Abusers: A Brain Source Space Study by Eeg, PLoS ONE (2019)

3. Olfactory Response As a Marker for Alzheimer's Disease: Evidence From Perceptual and Frontal Lobe Oscillation Coherence Deficit, PLoS ONE (2020)

4. Eeg-Based Functional Connectivity for Tactile Roughness Discrimination, Cognitive Neurodynamics (2023)

Experts (# of related papers)

View all Related Experts

Mohammadreza Nazemzadeh (1)

Bahador Makkiabadi (1)

Style	Citing Format
MLA	Salimi M, et al.. "Nasal Air Puff Promotes Default Mode Network Activity in Mechanically Ventilated Comatose Patients: A Noninvasive Brain Stimulation Approach." Neuromodulation, vol. 25, no. 8, 2022, pp. 1351-1363.
APA	Salimi M, Javadi AH, Nazari M, Bamdad S, Tabasi F, Parsazadegan T, Ayene F, Karimian M, Gholamimahtaj L, Shadnia S, Jamaati H, Salimi A, Raoufy MR (2022). Nasal Air Puff Promotes Default Mode Network Activity in Mechanically Ventilated Comatose Patients: A Noninvasive Brain Stimulation Approach. Neuromodulation, 25(8), 1351-1363.
Chicago	Salimi M, Javadi AH, Nazari M, Bamdad S, Tabasi F, Parsazadegan T, Ayene F, et al.. "Nasal Air Puff Promotes Default Mode Network Activity in Mechanically Ventilated Comatose Patients: A Noninvasive Brain Stimulation Approach." Neuromodulation 25, no. 8 (2022): 1351-1363.
Harvard	Salimi M et al. (2022) 'Nasal Air Puff Promotes Default Mode Network Activity in Mechanically Ventilated Comatose Patients: A Noninvasive Brain Stimulation Approach', Neuromodulation, 25(8), pp. 1351-1363.
Vancouver	Salimi M, Javadi AH, Nazari M, Bamdad S, Tabasi F, Parsazadegan T, et al.. Nasal Air Puff Promotes Default Mode Network Activity in Mechanically Ventilated Comatose Patients: A Noninvasive Brain Stimulation Approach. Neuromodulation. 2022;25(8):1351-1363.
BibTex	@article{ author = {Salimi M and Javadi AH and Nazari M and Bamdad S and Tabasi F and Parsazadegan T and Ayene F and Karimian M and Gholamimahtaj L and Shadnia S and Jamaati H and Salimi A and Raoufy MR}, title = {Nasal Air Puff Promotes Default Mode Network Activity in Mechanically Ventilated Comatose Patients: A Noninvasive Brain Stimulation Approach}, journal = {Neuromodulation}, volume = {25}, number = {8}, pages = {1351-1363}, year = {2022} }
RIS	TY - JOUR AU - Salimi M AU - Javadi AH AU - Nazari M AU - Bamdad S AU - Tabasi F AU - Parsazadegan T AU - Ayene F AU - Karimian M AU - Gholamimahtaj L AU - Shadnia S AU - Jamaati H AU - Salimi A AU - Raoufy MR TI - Nasal Air Puff Promotes Default Mode Network Activity in Mechanically Ventilated Comatose Patients: A Noninvasive Brain Stimulation Approach JO - Neuromodulation VL - 25 IS - 8 SP - 1351 EP - 1363 PY - 2022 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract