Ketoconazole and Ketoconazole/Β-Cyclodextrin Performance on Cotton Wound Dressing As Fungal Skin Treatment

Ketoconazole and Ketoconazole/Β-Cyclodextrin Performance on Cotton Wound Dressing As Fungal Skin Treatment Publisher Pubmed

Hedayati N¹ ; Montazer M¹ ; Mahmoudirad M² ; Toliyat T³

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1. Textile Engineering Department, Functional Fibrous Structures & Environmental Enhancement (FFSEE), Amirkabir Nanotechnology Research Institute (ANTRI), Amirkabir University of Technology, Tehran, Iran
2. Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Carbohydrate Polymers Published:2020

Abstract

Here, a cotton wound dressing was prepared with control release of Ketoconazole (KZ) to kill skin fungus. KZ alone and KZ/β-cyclodextrin (β-CD) were loaded on cotton through diverse methods. The drug release, antimicrobial activities against C. albicans, A. niger, E. coli and S. aureus and also cell cytotoxicity were studied. 1H NMR ensured the formation of KZ/β-CD complex, SEM images showed surface morphology and confirmed stability. KZ interestingly reacted with the cotton in the batch treatment possibly due to the two active chlorine groups, high temperature and relatively long treatment time. Good antifungal activities and slow release reported for the KZ treated fabric, however KZ/β-CD loaded more on the fabric with regular and slow release for longer time. The batch performed better than continuous method indicated good antifungal activities with more KZ loading and slower release. Also a cross-linking agent along with β-CD/KZ prolonged the release time with excellent washing stability. © 2020 Elsevier Ltd

2. Novel Cellulose Fabric With Multifunctional Properties Through Diverse Methods of Ag/Tio2/Β-Cyclodextrin Nanocomposites Synthesis, Cellulose (2018)

Experts (# of related papers)

Tayebeh Toliyat (2)

Nasrin Samadi (1)

Style	Citing Format
MLA	Hedayati N, et al.. "Ketoconazole and Ketoconazole/Β-Cyclodextrin Performance on Cotton Wound Dressing As Fungal Skin Treatment." Carbohydrate Polymers, vol. 240, no. , 2020, pp. -.
APA	Hedayati N, Montazer M, Mahmoudirad M, Toliyat T (2020). Ketoconazole and Ketoconazole/Β-Cyclodextrin Performance on Cotton Wound Dressing As Fungal Skin Treatment. Carbohydrate Polymers, 240(), -.
Chicago	Hedayati N, Montazer M, Mahmoudirad M, Toliyat T. "Ketoconazole and Ketoconazole/Β-Cyclodextrin Performance on Cotton Wound Dressing As Fungal Skin Treatment." Carbohydrate Polymers 240, no. (2020): -.
Harvard	Hedayati N et al. (2020) 'Ketoconazole and Ketoconazole/Β-Cyclodextrin Performance on Cotton Wound Dressing As Fungal Skin Treatment', Carbohydrate Polymers, 240(), pp. -.
Vancouver	Hedayati N, Montazer M, Mahmoudirad M, Toliyat T. Ketoconazole and Ketoconazole/Β-Cyclodextrin Performance on Cotton Wound Dressing As Fungal Skin Treatment. Carbohydrate Polymers. 2020;240():-.
BibTex	@article{ author = {Hedayati N and Montazer M and Mahmoudirad M and Toliyat T}, title = {Ketoconazole and Ketoconazole/Β-Cyclodextrin Performance on Cotton Wound Dressing As Fungal Skin Treatment}, journal = {Carbohydrate Polymers}, volume = {240}, number = {}, pages = {-}, year = {2020} }
RIS	TY - JOUR AU - Hedayati N AU - Montazer M AU - Mahmoudirad M AU - Toliyat T TI - Ketoconazole and Ketoconazole/Β-Cyclodextrin Performance on Cotton Wound Dressing As Fungal Skin Treatment JO - Carbohydrate Polymers VL - 240 IS - SP - EP - PY - 2020 ER -

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