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Global Prevalence of Colistin Resistance in Clinical Isolates of Acinetobacter Baumannii: A Systematic Review and Meta-Analysis Publisher Pubmed



Pormohammad A1 ; Mehdinejadiani K2 ; Gholizadeh P3 ; Mohtavinejad N4 ; Dadashi M5 ; Karimaei S6 ; Safari H7 ; Azimi T6, 8
Authors
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Authors Affiliations
  1. 1. Student Research Committee, Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Microbiology Immunology and Infectious Diseases University of Calgary, Canada
  3. 3. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Department of Radio Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Microbiology, School of Medicine, Alborz University of Medical Sciences, Tehran, Iran
  6. 6. Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Health Promotion Research Center, Iran University of Medical Sciences, Tehran, Iran
  8. 8. Students Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Microbial Pathogenesis Published:2020


Abstract

Introduction: Acinetobacter baumannii antimicrobial resistance is a public health concern in developing and developed countries, especially in the hospital setting. Understanding the antibiotic resistance profile can help to provide better guidelines for the prescription of appropriate antibiotics, reduction of antibiotic resistance, and introducing new and effective treatment options. Method: Using the PRISMA guidelines, databases of PubMed, Embase, and Cochrane Library were searched systematically from January 1, 2000, to January 1, 2018. All statistical analyses were carried out via Comprehensive Meta-Analysis Software Version 2.0 (Biostat, Englewood, NJ). Depending on the heterogeneity test, either random or fix effect models were used for determining the pooled prevalence of drug resistance. Result: A total of 150 studies were included from 41 countries of six different WHO regional offices worldwide. The highest and the lowest rate of resistance were observed for cefotaxime (99%, 95% CI: 95–99.9) in Africa and colistin (1.1%, 95% CI: 0.3–4.5) in Western Pacific, respectively. Lebanon (17.5%, 95% CI: 16–19) and China (12%, 95% CI: 3.5–32.5) had the highest and Germany (0.2%, 95% CI: 0–2.5) had the lowest rate of resistance for colistin. Conclusion: Our analysis showed that prevalence and rate of increased colistin resistance in South-East Asia and Eastern Mediterranean countries are higher than other regions of the world. Therefore, the establishment of appropriate antibiotic usage guidelines should be essential in these countries. © 2019
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